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Augmented cognitive training

a cognitive training and augmented technology, applied in the field of augmented cognitive training, can solve the problems of affecting the autonomy and quality of life of individuals, affecting the autonomy of individuals, and the cognitive training protocol is often very costly and time-consuming, so as to improve the ability or function of normal cognitive performance, enhance the effect of normal cognitive performance in an animal and improve the effect of normal cognitive performan

Inactive Publication Date: 2011-09-15
TULLY TIMOTHY P +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a method for improving cognitive performance in animals, particularly humans, by enhancing the function of the CREB pathway using a combination of a specific training protocol and administration of a CREB pathway-enhancing drug. This method can be used for rehabilitating animals with cognitive dysfunction or enhancing normal cognitive performance. It can be applied in various settings such as brain training, stroke rehabilitation, and learning disabilities. The method requires fewer training sessions and can lead to faster and more efficient recovery of lost cognitive function. Overall, this invention offers a more efficient and effective way to improve cognitive performance."

Problems solved by technology

Cognitive dysfunction causes significant impairment of social and / or occupational functioning, which can interfere with the ability of an individual to perform activities of daily living and greatly impact the autonomy and quality of life of the individual.
Because multiple training sessions are often required before an improvement or enhancement of a specific aspect of cognitive performance (ability or function) is obtained in the individuals, cognitive training protocols are often very costly and time-consuming.

Method used

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  • Augmented cognitive training

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second embodiment

[0048]In a second embodiment, the invention relates to a method of treating a cognitive deficit associated with a neurodegenerative disease (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, other senile dementia) in an animal in need of said treatment comprising (a) administering to the animal an augmenting agent which enhances CREB pathway function; and (b) training the animal under conditions sufficient to produce an improvement in performance by the animal of a cognitive task whose deficit is associated with the neurodegenerative disease.

third embodiment

[0049]In a third embodiment, the invention relates to a method of treating a cognitive deficit associated with a psychiatric disease (e.g., depression, schizophrenia, autism, attention deficit disorder) in an animal in need of said treatment comprising (a) administering to the animal an augmenting agent which enhances CREB pathway function; and (b) training the animal under conditions sufficient to produce an improvement in performance by the animal of a cognitive task whose deficit is associated with the psychiatric disease.

fourth embodiment

[0050]In a fourth embodiment, the invention relates to a method of treating a cognitive deficit associated with trauma dependent loss of cognitive function (e.g., cerebrovascular diseases (e.g., stroke, ischemia), brain tumor, head or brain injury) in an animal in need of said treatment comprising (a) administering to the animal an augmenting agent which enhances CREB pathway function; and (b) training the animal under conditions sufficient to produce an improvement in performance by the animal of a cognitive task whose deficit is associated with trauma dependent loss of cognitive function.

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Abstract

The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.

Description

RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Application No. 60 / 224,227, filed on Aug. 10, 2000. The entire teachings of this application are incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]An estimated 4 to 5 million Americans (about 2% of all ages and 15% of those older than age 65) have some form and degree of cognitive failure. Cognitive failure (dysfunction or loss of cognitive functions, the process by which knowledge is acquired, retained and used) commonly occurs in association with central nervous system (CNS) disorders or conditions, including age-associated memory impairment, delirium (sometimes called acute confusional state), dementia (sometimes classified as Alzheimer's or non-Alzheimer's type), Alzheimer's disease, Parkinson's disease, Huntington's disease (chorea), cerebrovascular disease (e.g., stroke, ischemia), affective disorders (e.g., depression), psychotic disorders (e.g., schizophrenia, autism (Kanner's Sy...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/7088A61P25/28A61P25/24A61P25/18A61K31/00A61K38/17A61K48/00
CPCA61K31/00A61K38/1709G09B19/00A61N1/30A61K48/00A61P25/18A61P25/24A61P25/28A61K31/522
Inventor TULLY, TIMOTHY P.CAVALIERI, FILIPPO
Owner TULLY TIMOTHY P
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