Method of Using Dihydro-Resveratrol for Treating Acute Pancreatitis and Associated Pulmonary Injury

a technology of acute pancreatitis and dihydroresveratrol, which is applied in the field of using dihydroresveratrol for acute pancreatitis, can solve the problems of multi-organ dysfunction syndrome that affects distant organs, and the mortality rate of severe acute pancreatitis remains relatively high, so as to reduce hyperamylasemia, restore pancreatic glutathione levels, and reduce the formation of interstitial edema and thickening of the alv

Active Publication Date: 2016-12-22
HONG KONG BAPTIST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005]Accordingly, the objective of the present invention relates to a method of using an effective amount of dihydro-resveratrol or its stilbenoid derivatives and / or chemical variants as a potential remedial agent for the treatment and / or alleviation of inflammatory conditions such as acute pancreatitis and associated systemic complications including pulmonary injury in a subject in needs thereof. Dihydro-resveratrol effectively reduces hyperamylasemia, acinar shrinkage, alveolar wall thickening and interstitial edema formation in the pancreas and lungs. Further, dihydro-resveratrol inhibits the production of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) and myeloperoxidase (MPO) activity while restoring pancreatic levels of glutathione. Importantly, oral administration of dihydro-resveratrol shows no adverse effects in the animal trial.

Problems solved by technology

Although acute pancreatitis is an inflammatory process originated in the pancreas, it often leads to multi-organ dysfunction syndrome that affects distant organs.
Organ failure and multiple organ system failure in pancreatitis.
Unfortunately, there is no effective therapeutic procedure so that the mortality rate of severe acute pancreatitis stays relatively high.

Method used

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  • Method of Using Dihydro-Resveratrol for Treating Acute Pancreatitis and Associated Pulmonary Injury
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  • Method of Using Dihydro-Resveratrol for Treating Acute Pancreatitis and Associated Pulmonary Injury

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first embodiment

[0058]In a first aspect of the present invention there is provided a method of treating acute inflammatory condition of the pancreas and associated systemic complications by administering to a subject in needs thereof a composition comprising an effective amount of a stilbenoid derivative which comprises a compound of formula (1),

wherein R1, R2 and R3 are each independently selected from an alkyl group. The term “alkyl”, alone or in combination with other groups, includes reference to a straight chain alkyl moiety having 1, 2, 3, 4, 5 or 6 carbon atoms. The term is further exemplified by such groups as methyl, ethyl, propyl (n-propyl or isopropyl), butyl (n-butyl, sec-butyl and tert-butyl), pentyl, hexyl and the like, and the derivatives or chemical variants thereof; or a mixture of said compound, the derivative and / or chemical variants thereof.

second embodiment

[0059]In a first aspect of the present invention there is provided a method of treating acute inflammatory condition of the pancreas and associated systemic complications wherein the stilbenoid derivative is trans-3,5,4′-trihydroxybibenzyl, or dihydro-resveratrol, which is a compound of formula (2):

and the derivatives or chemical variants thereof; or a mixture of said compound, the derivative and / or chemical variants thereof.

third embodiment

[0060]In the first aspect of the present invention there is provided a method of treating acute inflammatory condition of the pancreas and associated systemic complications wherein the subject is a human or an animal.

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Abstract

The present invention relates to a method of using trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and / or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.

Description

FIELD OF INVENTION[0001]The present invention relates to a method of using dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using a polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.BACKGROUND OF INVENTION[0002]Acute pancreatitis is an inflammatory condition that happens as a sudden onset resulting from the premature activation of proteolytic zymogens occurring within the exocrine pancreas. The abnormally activated zymogens escape into the interstitium of the pancreas and cause autodigestion of the gland as reported in Grady T, Mah'Moud M, Otani T, Rhee S, Lerch M M, Gorelick F S. Zymogen proteolysis within the pancreatic acinar cell is...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/09C07C37/00C07C39/15
CPCA61K31/09C07C37/003C07C39/15A61K31/05A61P1/18A61P29/00
Inventor BIAN, ZHAOXIANGTSANG, SIU WAIZHANG, HONGJIELU, AIPINGCHAN, ALBERT SUN-CHI
Owner HONG KONG BAPTIST UNIV
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