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Methods and compositions for the treatment of post-traumatic stress disorder

a post-traumatic stress disorder and composition technology, applied in the field of post-traumatic stress disorder, can solve problems such as autonomic arousal, and achieve the effect of increasing the blood brain barrier permeability

Inactive Publication Date: 2017-02-02
GENOMIND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method for determining if a patient will benefit from treatment with an ARB drug therapy by analyzing the patient's autonomic arousal axis, specifically by examining the genes that make up this axis. This method can help identify patients with disturbances in this axis, such as those with heightened arousal, panic, intractable anxiety, and PTSD. By identifying these biomarkers, treatment with angiotensin receptor blockers like candesartan can be initiated to reduce autonomic hyperactivity.

Problems solved by technology

Dysregulation of these pathways may result in problems of autonomic arousal.

Method used

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  • Methods and compositions for the treatment of post-traumatic stress disorder
  • Methods and compositions for the treatment of post-traumatic stress disorder

Examples

Experimental program
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Effect test

example 1

FKBP5 Assay

[0206]Single nucleotide determination: Genetic variation in the FKBP5 gene confers altered cortisol function and a poorly regulated neuroendocrine response to stress. A single nucleotide polymorphism (SNP) in FKBP5 (C to T SNP in intron 2, rs1360780) increases the ability of the GR to bind to the glucocorticoid response elements and induce FKBP5 expression. This “risk” T allele is associated with GR resistance and has been linked with PTSD, depressive and anxiety symptoms and disorders, and suicide.

[0207]FKBP5 Epigenetic assessment: Methylation of FKBP5. Methylation of the FKBP5 gene can also be contemplated as an element of the disclosure. Methylation of CPG islands of FKBP5 decreases the induction of FKBP5 that occurs following glucocorticoid binding to GR, and demethylation can be induced by prolonged glucocorticoid exposure. Sodium bisulfite modification of DNA using the EZ DNA methylation Kit and reverse primers can be used to amplify FKBP5 intron 7 as previously des...

example 2

Clinical Example

[0210]CLINICAL: a 34 year old war combat war veteran suffered symptoms of PTSD, including frequent nightmares, avoidance behavior and recurrent experiencing of the original trauma. His history was also remarkable for a blast injury due to an IED explosion that killed a member of his platoon. On return from active duty he was treated with several different antidepressants with no beneficial response. An MRI of the brain was completed which was reported as negative. He was moderately hypertensive and had chronic back problems and pain and sometimes used pain killers, including Percocet. He was prescribed telmisartan 40 mg and the dose was steadily increased to lower his blood pressure. PTSD symptoms did not seem to improve until the inventor added a low dose of minocycline, 100 mg daily. After 3 weeks on this regime, he noticed a decline in his anger and depression, as well as a reduction in headaches with improved concentration.

[0211]When a feature or element is herei...

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Abstract

Methods and compositions are disclosed to treat neuropsychiatric disorders post-traumatic stress disorder (PTSD). In particular, described herein are angiotensin receptor blockers (ARBs), and in particular the combination of one or more ARB (such as telmisartan) and an agent that enhances the delivery of the ARB across the blood-brain barrier (such as minocycline). PTSD may be treated using a combination of telmisartan and minocycline at levels of each that are, by themselves, infective to treat PTSD. Also described herein are methods for treating PTSD by first identifying patents for whom the use of an ARB treatment would be effective, by determining that patient has a dysfunction in their angiotensin converting enzyme and / or other genes in the autonomic arousal axis.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This patent application claims priority as a continuation-in-part of U.S. patent application Ser. No. 13 / 937,168, filed Jul. 8, 2013, titled “METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS,” Publication No. US-2013-0295203-A1, which claims priority to the following provisional patent applications: U.S. Provisional Patent Application No. 61 / 669,423, filed Jul. 9, 2012, titled “MEDICAL FOODS FOR THE TREATMENT OF SUBTYPES OF AUTISM AND METHODS OF USE;” U.S. Provisional Patent Application No. 61 / 674,240, filed Jul. 20, 2012, titled “USE OF THE COMT ACTIVITY TO GUIDE TREATMENT OF SUBTYPES OF DEPRESSION AND CHRONIC PAIN SYNDROMES;” U.S. Provisional Patent Application No. 61 / 674,247, filed Jul. 20, 2012, titled “COMPANION DIAGNOSTIC-BASED MEDICAL FOOD FOR TREATMENT OR PREVENTION OF DEMENTIA;” U.S. Provisional Patent Application No. 61 / 693,740, filed Aug. 27, 2012, titled “COMPANION DIAGNOSTICS AND MEDICAL FOOD INTERVENT...

Claims

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Application Information

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IPC IPC(8): C12Q1/68A61K31/4184A61K31/65A61K31/4178
CPCC12Q1/6883A61K31/4178A61K31/4184C12Q2600/106C12Q2600/156C12Q2600/154A61K31/65A61K45/06A61K31/185A61K31/19A61K31/197A61K31/352A61K31/353A61K31/519A61K31/685A61K31/7076A61K33/06A23V2002/00A23L33/10
Inventor LOMBARD, JAY L.
Owner GENOMIND
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