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Capacitive feedback (transimpedance) amplifier for use with nanopore detection and sequencing device

a technology of capacitive feedback and amplifier, which is applied in the direction of instruments, biochemical instruments and processes, material analysis, etc., can solve the problems of reducing the integration area of the integrator, reducing the read-length, and requiring care to achieve the precise resistance desired of pseudo-resistors, etc., to achieve low input-referred noise current, reduce the integrator area, and reduce the effect of resistan

Inactive Publication Date: 2017-05-25
RGT UNIV OF CALIFORNIA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

This patent is about a new invention that was made with the help of a government grant (NSF Contract / grant No. ECCS-0845766). The government has certain rights in this invention. Its technical effects will require further analysis and interpretation.

Problems solved by technology

Therefore, implementing high gain and low noise amplifiers using the resistive feedback configuration on a semiconductor chip is problematic because that high value resistances (at least tens of mega-Ohms) that are suitable for use as feedback resistors RF 507 require large chip areas.
The latest sequencing device from Ion Torrect (now part of Life Technologies) has 1.2 Million addressable measurement wells (but read-length is limited by the use of enzymes for sequencing).
One drawback of pseudo-resistors is that pseudo-resistors require care to achieve precise resistance desired.

Method used

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  • Capacitive feedback (transimpedance) amplifier for use with nanopore detection and sequencing device
  • Capacitive feedback (transimpedance) amplifier for use with nanopore detection and sequencing device
  • Capacitive feedback (transimpedance) amplifier for use with nanopore detection and sequencing device

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Embodiment Construction

[0042]The presently disclosed subject matter now will be described more fully hereinafter with reference to the accompanying drawings in which one embodiment is shown. However, it should be understood that this invention may take many different forms and thus should not be construed as being limited to the embodiment set forth herein.

[0043]All documents and references referred to in this disclosure are hereby incorporated by reference for all purposes. In the figures like numbers refer to like elements throughout. Additionally, the terms “a” and “an” herein do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced items.

[0044]International application “Dual Pore Device” (WO 2013 / 012881) is hereby incorporated by reference in its entirety for all purposes. Additionally, the terms “a” and “an” herein do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced items.

[0045]Several embodiments of ...

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Abstract

A multiplexed nanopore sensing network comprising an integrated and multiplexed network of patch clamp capacitive integrator-differentiator amplifiers with small feedback capacitors using pseudo-resistors.

Description

RELATIONSHIP TO OTHER APPLICATIONS[0001]This application is a divisional of pending U.S. application Ser. No. 14 / 438,868 filed 27 Apr. 2015 which is a national phase of PCT / US13 / 67132, which claims the benefit of U.S. Provisional Application No. 61 / 719,443, entitled “Multiplexing Electronic Configuration for Multichannel Nanopore Sensing,” which was filed 28 Oct. 2012.STATEMENT OF SUPPORT[0002]This invention was made with government support under NSF Contract / grant No. ECCS-0845766 awarded by the National Science Foundation. The government has certain rights in this invention.FIELD OF THE INVENTION[0003]The presently disclosed subject matter is directed towards high density multiplex nanopore sensing, for use in, for example, high-throughput sequencing.BACKGROUND[0004]Nanopore sequencing technology allows one to measure the ionic current generated by a molecule moving across the nanopores thereby identifying the molecule. An ionic current is a current generated by the flow of ions. ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68G01N27/447H03F3/45
CPCC12Q1/6809H03F3/45475H03F2203/45528H03F2200/261H03F2203/45512G01N27/44791H03F2200/411H03F2203/45411C12Q1/6869H03F3/45076G01N27/447H03F2203/45336H03F3/45H03F1/34
Inventor KIM, JUNGSUKDUNBAR, WILLIAM
Owner RGT UNIV OF CALIFORNIA
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