Use of trpc6 mRNA levels in peripheral blood cells for early detection/diagnosis of senile dementia

a technology of peripheral blood cells and mrna, applied in the field of biotechnology, can solve the problems of low specificity and sensitivity of mmse, inability to detect ad by using ad-secretase inhibitors, and possible interference of many substrates with normal physiological functions of secretase inhibitors, so as to achieve the effect of reducing a levels
US20180066314A1Inactive Publication Date: 2018-03-08AGING WISE BIOTECH INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
AGING WISE BIOTECH INC
Publication Date
2018-03-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the use of TRPC6 mRNA levels in peripheral blood cells for the early detection / diagnosis of senile dementia. Specifically, the present invention provides a classic transient receptor potential channel 6 (TRPC6) gene or protein thereof and the use of same in preparing a reagent or test kit for detecting or diagnosing Alzheimer's disease. The present invention further relates to a polypeptide used to prepare a medicament that treats AD, and relates to a composition of said polypeptide.
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Description

RELATED APPLICATIONS

[0001] This application is a divisional application of U.S. Ser. No. 14 / 765,715, filed on Aug. 4, 2015, which is a national stage filing under 35 U.S.C. § 371 of International Application PCT / CN2014 / 071325 entitled “USE OF TRPC6 MRNA LEVELS IN PERIPHERAL BLOOD CELLS FOR EARLY DETECTION / DIAGNOSIS OF SENILE DEMENTIA” filed Jan. 24, 2014, which claims priority to CN Application No. 201310044282.0, filed Feb. 4, 2013, the entire disclosure of each of which is incorporated by reference in its entirety.TECHNIQUE FIELD

[0002] The present invention relates to the biotechnology field, specifically, relates to the use of Transient Receptor Potential Canonical 6 (TRPC6) gene or protein thereof, for preparing the reagent or kit for the prediction or diagnosis of Alzheimer disease (AD). The present invention also relates to a polypeptide and composition thereof for preparing a medicament for treating AD.BACKGROUND

[0003] Alzheimer's disease, namely senile dementia, is the most com...

Claims

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