Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
a technology of nitric oxide and nail coating, which is applied in the direction of dental surgery, pedicure, dental tools, etc., can solve the problems of drug penetration to the nail bed, high potential systemic adverse effects,
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example 1
ail Lacquer
[0138]Vehicle nail lacquer solutions were initially prepared to evaluate the film-forming potential, upon solvent evaporation, of formulations comprised of a single polymer. Additional nail lacquer vehicles were prepared to evaluate formulations containing combinations of a strong film-forming polymer and a hydrophilic polymer. While not wishing to be bound to any particular theory, the intention of the binary polymer formulations is that the hydrophilic polymer will form channels within a robust, protective film allowing moisture penetration without disrupting or dissolving the film.
[0139]The vehicle nail lacquers were prepared by first mixing weighed amounts of the solvents and emollient in a 250-mL glass beaker. The weighed amount of polymer was then dissolved in the mixture using an IKA T-18 Homogenizer at a low-to-medium speed setting. The resulting solution was transferred to a 20-mL glass vial, and the visual appearance of the solution was recorded as provided in T...
example 2
ide Releasing Nail Lacquer
[0141]A diazeniumdiolate-functionalized co-condensed silica (Nitricil™) was prepared according to known methods and milled Nitricil™ is a NO-releasing co-condensed silica, from Novan, Inc. and may be provided with one or more different release profiles and / or functional groups, such as, but not limited to, diazeniumdiolate-functionalized co-condensed silica. Nitricil™ was analyzed for nitric oxide (NO) content, moisture content, and the particle size distribution of pre-milled and milled Nitricil™ was determined prior to initiation of the formulation development. The results from the analyses are summarized in Table 3.
TABLE 3Diazeniumdiolate-functionalized Co-Condensed Silica PropertiesParticle SizeParticle SizeMoistureDistribution -Distribution -NO ContentContentPre-MilledMilledResult4.57 μmol / mg6.1% w / wD10: 18.90 μmD10: 1.25 μm(13.71% w / w)D50: 442.38 μmD50: 4.34 μmD90: 843.41 μmD90: 10.59 μm
[0142]The initial development of the Nitricil™ Nail Lacquer was b...
example 3
l Vehicle Nail Lacquers
[0144]Additional example vehicle nail lacquers are provided in Formulas 1-5 below. A NO-releasing compound (e.g., a diazeniumdiolate-functionalized co-condensed silica) may be added to an example vehicle nail lacquer in an amount of about 0.1% to about 70% by weight of the lacquer composition.
Formula 1
[0145]
Ingredient% / WeightFunctionIsopropyl Alcohol65-85SolventNitrocellulose 1-12Film FormerAdipic Acid / Neopentyl 1-12Film FormerGlycol / TrimelliticAnhydride CopolymerTrimethyl Pentanyl1-6PlasticizerDiisobutyrateTriphenyl Phosphate1-6PlasticizerStearalkonium Hectorite1-2Thickening AgentBenzophenone-10.1AntioxidantTitanium DioxideQuantity sufficientColorant
Formula 2
[0146]
Ingredient% / WeightFunctionPNVA1-3 Film FormerIsopropyl Alcohol30-80 SolventPropylene Glycol1-10SolventGlycerine1-10Solvent
Formula 3
[0147]
Ingredient% / WeightFunctionGantrez S-971-10Film FormerIsopropyl Alcohol30-80 SolventPropylene Glycol1-10SolventGlycerin1-10Solvent
Formula 4
[0148]
Ingredient% / WeightF...
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