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Compositions and methods for treating bone fractures

Pending Publication Date: 2022-08-25
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a better way to repair fractures without needing to cut the skin or use temporary bags to hold cement. It uses a strong carbon fiber tube and a biocompatible polymer to create a very strong bond inside the bone. This method reduces trauma and recovery time, and can be left in place permanently or removed if necessary. It also avoids interference with MRI and other medical imaging techniques. Overall, this new technique offers a better solution for repairing bones.

Problems solved by technology

Such incisions typically create significant trauma and require extensive rehabilitation time.
However, these, and other existing solutions fail to meet the need for a bone repair, strengthening system, and an infection prevention system that is permanent (e.g., non-absorbable), while providing the option for removal and further fail to provide a customizable solution for each patient's need.
In some embodiments, the subject is at increased risk of a fracture (e.g., due to overuse, injury, or disease (e.g., osteoporosis).

Method used

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  • Compositions and methods for treating bone fractures
  • Compositions and methods for treating bone fractures
  • Compositions and methods for treating bone fractures

Examples

Experimental program
Comparison scheme
Effect test

example 1

Fixation of a Fractured Humerus in a Human Patient

[0074]The following example describes treatment strategies for a fractured humerus involving a treatment method of embodiments of the present invention.

[0075]A 25 year old human male patient presents with a fractured humerus. The bone was broken in an automobile accident. He visits a physician and undergoes x-ray imaging. He is diagnosed with a compound fracture of the right humerus. The physician recommends minimally invasive fixation using an intramedullary carbon fiber tube. The patient is sedated and treated with a bone repair system described herein. During his follow up visit with his physician, the patient undergoes additional x-ray imaging which shows that the bone is healing. The patient continues to improve and regains full use of the right arm within 3 months. No side effects are reported.

example 2

Reinforcement of a Hip Bone in a Patient with Osteoporosis

[0076]The following example describes treatment strategies for strengthening of a hip bone involving reinforcement with a carbon fiber tube of embodiments of the present invention. A 71 year old woman is diagnosed with severe osteoporosis. A physician treats the woman with a bone strengthening repair system described herein. The patient continues to improve and is able to walk normally within 3 months. No side effects are reported.

example 3

Fixation of Fractured Equine Tibia

[0077]The following example describes a treatment strategy for an equine with a fractured tibia involving implantation of a carbon fiber tube of embodiments of the present invention.

[0078]A 3 year old male racehorse presents with a weakness in the left foreleg. A veterinary surgeon diagnoses the horse with a fractured tibia. The surgeon repairs the bone with a bone repair system described herein. The horse continues to improve and is functioning normally at 4 months. No side effects are reported.

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PUM

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Abstract

Provided herein are compositions and methods for treating bone fractures. In particular, provided herein are systems comprising carbon fiber sleeves and biocompatible polymers and the use of such systems in treating or preventing bone fractures.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to and the benefit of U.S. Provisional Application No. 62 / 878,484, filed Jul. 25, 2019, which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]Provided herein are compositions and methods for treating and stabilizing bone fractures. In particular, provided herein are systems comprising fiber sleeves and biocompatible polymers and the use of such systems in treating bone fractures.BACKGROUND OF THE INVENTION[0003]A bone fracture is a medical condition where the continuity of the bone is broken. A significant percentage of bone fractures occur because of high force impact or stress. However, a fracture may also be the result of medical conditions that weaken the bones, for example osteoporosis, some cancers, or osteogenesis imperfecta.[0004]Bone healing is a process which in most cases occurs naturally. Fracture treatment is usually aimed at making sure there is the best possib...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/08A61L27/56A61L27/54
CPCA61F2/2846A61L27/08A61L27/56A61L27/54A61L2300/404A61F2002/2839A61F2310/00161A61B17/72A61F2/28A61F2002/2825A61F2002/2835A61F2002/307A61F2/30965A61B17/7258A61F2002/30677A61F2002/3084A61F2002/30919A61F2310/00155A61F2310/00574
Inventor SAADATMANESH, HAMIDZARKOOB, MEHRNOOSH
Owner THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA