Imaging device for optically extracting features of an object
a technology of optical extraction and features, applied in the field of imaging, can solve the problems of difficult to achieve high-resolution image acquisition, difficult to achieve image acquisition time-consuming imaging of a full microarray, etc., to achieve the effect of maintaining or increasing the size of acquired images and maintaining the resolution of acquired images
Inactive Publication Date: 2009-04-07
NATIONAL TSING HUA UNIVERSITY +1
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Benefits of technology
"The present invention provides a method and device for optically extracting discrete features of an object. This allows for the small regions of interest or features within a relatively large object to be optically extracted and collated into a single, condensed image. The device contains a plurality of image conduits with image conduits having first and second ends. The first ends of the image conduits are guided into a first pattern and the second ends are guided into a second pattern. The first pattern corresponds to the pattern of discrete features on the object, while the second pattern is a spatially rearranged version of the first pattern. The device also includes one or more lenses to magnify the images of the discrete features. The invention allows for the optical extraction of discrete features of an object and the simultaneous visualization of spatially separated features on a surface of a 3-dimensional object."
Problems solved by technology
Traditional imaging systems do not allow high resolution imaging of relatively small features without a corresponding expansion of the field of view.
These systems require complicated software to automate visual inspection and measurement of the spots.
In this case, the imaging of a full microarray the can be very time consuming.
Method used
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[0014]The present invention provides an imaging device for optically extracting discrete features of an object. FIG. 1 illustrates an example of an imaging device according to the present invention. FIG. 1A shows a cross section of imaging device 100. Imaging device 100 has 48 image conduits 110, 12 of which can be seen in this cross section. Each of the image conduits 110 has a first end 112 and a second end 114. The first ends 112 serve to acquire images of features 120 of object 122 through lens 130. The image conduits are fixed in position by first penetrating layer 140, second penetrating layer 150, and flexible layer 160, for example by compressing flexible layer 160 between first penetrating layer 140 and second penetrating layer150. Once images have been acquired, they are optically transmitted through image conduits 110 to second ends 114. The images are then collected by image capturing element 170.
[0015]FIG. 1B and FIG. 1C are planar sections of the bottom of first penetr...
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The present invention provides a method and device for optically extracting discrete features of an object. With this method and device, small regions of interest or features within a relatively large object are optically extracted and collated into a single, condensed image. The condensed image contains all of the features in the original object, but not the parts of the object that are between the features. Thus, the optically extracted features can be viewed at high resolution, but in a limited field of view. Examples of objects that may be optically extracted according to the invention include spots of biomaterial on a biochip, material in wells of a microtiter plate, etc. In addition, this device and method can be used for non-planar objects. In this case, the device and method allow simultaneous visualization of spatially separated features on a surface of a 3-dimensional object.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority from Taiwanese application number 94100385, filed Jan. 6, 2005, which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to imaging. More particularly, the present invention relates to methods and devices for optically extracting discrete features of an object.BACKGROUND[0003]There are many applications for which features of interest are small compared to the size of the object. For example, in microarrays and other biochips, small spots of nucleic acids or other biomolecules are spatially separated into an array of spots. Similarly, in microtiter plates, substances in wells are small compared to the size of the plate. Traditional imaging systems do not allow high resolution imaging of relatively small features without a corresponding expansion of the field of view. For example, if one were to take an image of a microarray at a high enough resolution to ...
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IPC IPC(8): G02B6/42
CPCG02B6/06
Inventor COLLER, JR., JOHN A.FERO, MICHAEL J.HSU, IAN C.HUANG, CHING-LUNG
Owner NATIONAL TSING HUA UNIVERSITY