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Composition of ginseng-astragalus polysaccharides and its preparing method

A technology of Shenqi polysaccharide and composition is applied in the field of Shenqi polysaccharide composition and its preparation, which can solve the problems of increasing the risk of adverse reactions and the like, and achieve the effects of strong immune enhancement effect, definite curative effect and stable quality.

Inactive Publication Date: 2007-11-21
广东仁泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Shenqi Fuzheng Injection currently produced in the market has a wide range of indications. When it is used for anti-tumor adjuvant drugs and other immune-enhancing effects, the risk of adverse reactions is increased due to the presence of saponins, and not all polysaccharides The ingredients are all active ingredients. According to research, only polysaccharides with a certain molecular weight range are active.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of Shenqi polysaccharide

[0023] Take 5kg of Codonopsis pilosula and 5kg of Astragalus membranaceus and crush them into coarse particles, add 60 liters of 90% medicinal ethanol to extract at 80°C for 3 hours, release the extract, then add 60 liters of 90% ethanol to extract at 80°C for 2 hours, combine the two extracts for recovery ethanol. Drain the dregs, evaporate the solvent, add 70 liters of deionized water to reflux for extraction for 2 hours, release the extract, then add 70 liters of deionized water to reflux for extraction for 2 hours, combine the two water extracts for filtration, and then concentrate the filtrate under reduced pressure to a relative density of 1.15-1.25 Between them (measured value 1.18), add 95% medicinal ethanol to 75% ethanol concentration under constant stirring, and let it stand for 24 hours to separate solid and liquid to obtain crude polysaccharide. The crude polysaccharide is fully dissolved in 15 liters of...

Embodiment 2

[0024] Embodiment 2: Preparation of Shenqi polysaccharide

[0025] Take 5kg Codonopsis pilosula and 5kg Astragalus membranaceus and crush them into coarse particles, add 70 liters of 85% medicinal ethanol to extract at 80°C for 3 hours, release the extract, then add 70 liters of 85% ethanol to extract at 80°C for 2 hours, combine the two extracts for recovery ethanol. Drain the dregs, evaporate the solvent, add 90 liters of deionized water to reflux for extraction for 2 hours, release the extract, then add 90 liters of deionized water to reflux for extraction for 2 hours, combine the two water extracts for filtration, and then concentrate the filtrate under reduced pressure to a relative density of 1.15-1.25 Between them (measured value 1.23), add 95% medicinal ethanol to 85% ethanol concentration under constant stirring, let stand for 24 hours, and separate solid and liquid to obtain crude polysaccharide. The crude polysaccharide is fully dissolved in 15 liters of deionized ...

Embodiment 3

[0026] Embodiment 3: Preparation of Shenqi polysaccharide

[0027] Take 5kg Codonopsis pilosula and 5kg Astragalus membranaceus and crush them into coarse particles, add 80 liters of 80% medicinal ethanol to extract at 80°C for 3 hours, release the extract, then add 80 liters of 80% ethanol to extract at 80°C for 2 hours, combine the two extracts for recovery ethanol. Drain the dregs, evaporate the solvent, add 70 liters of deionized water to reflux for extraction for 2 hours, release the extract, then add 70 liters of deionized water to reflux for extraction for 2 hours, combine the two water extracts for filtration, and then concentrate the filtrate under reduced pressure to a relative density of 1.15-1.25 Between them (measured value 1.25), add 95% medicinal ethanol to 80% ethanol concentration under constant stirring, let stand for 24 hours, and separate solid and liquid to obtain crude polysaccharide. The crude polysaccharide is fully dissolved in 15 liters of deionized ...

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Abstract

The present invention relates to a shenqi polysaccharide composition. It is formed from polysaccharides which are respectively extracted by utilizing 1-3 portions of pilose asiabell root and 1-3 portions of astragalus root and purified, in which the polysaccharide content whose molecular weight range is 10000-10000 is above 80% of total solid substance content. It can be made into shenqi polysaccharide injection and injection freeze-dried powder, and its quality is stable, and can be controlled. Said invention has strong immunologic enhancement.

Description

Technical field: [0001] The invention relates to a ginseng polysaccharide composition for enhancing immunity and a preparation method thereof. Background technique: [0002] Shenqi Fuzheng Injection is a traditional Chinese medicine injection made by extracting active ingredients from Codonopsis pilosula and Radix Astragali. It has the functions of strengthening the body, improving the immune function of the human body, and improving the symptoms of patients. It is often used in clinical adjuvant therapy for tumors. However, due to the complex composition of traditional Chinese medicine injection, Shenqi Fuzheng Injection was developed earlier, and the technical conditions at that time were backward, and there were inevitable problems in the degree of purification and quality control of the drug, which increasingly failed to meet the requirements of modern clinical medication. . Some clinical adverse reactions occur from time to time, for example: one case of severe rash ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K36/481A61K36/344A61P37/04
Inventor 王伟刘二伟
Owner 广东仁泰药业有限公司
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