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Pylorus screw bacterium fenestra element having adhesion function

A technology of DNA molecules and nucleotide sequences, which is used in medical preparations containing active ingredients, bacterial peptides, organic chemistry, etc.

Inactive Publication Date: 2008-04-02
NAN FANG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, induces a specific systemic immune response to H. pylori antigens; however, the formation of secretory antibodies (slgA) in the stomach has not been uncontroversially elucidated

Method used

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  • Pylorus screw bacterium fenestra element having adhesion function
  • Pylorus screw bacterium fenestra element having adhesion function

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Embodiment Construction

[0026] The present invention will be described in further detail below in conjunction with the accompanying drawings and Examples: As shown in Figures 1 to 3, the DNA molecule is characterized in that it comprises: (a) the nucleotide sequence shown in the sequence number 1, (b) a nucleotide sequence corresponding to the sequence in (a) within the scope of the degeneracy of the genetic code, or, (c) a nucleoside that hybridizes to the sequence of (a) or / and (b) under stringent conditions acid sequence; at the nucleic acid level, it has at least 90% homology with the nucleotide sequence shown in SEQ ID NO: 1; its length is at least 45 nucleotides; (a) it encodes a human The polypeptide of the cell, (b) the vector contains at least one copy of the DNA molecule, (c) the cell is transformed by the vector; the polypeptide, which is encoded by the DNA molecule, includes: (a) the nucleotide sequence shown in SEQ ID NO: 1 , or, (b) a nucleotide sequence that immunologically cross-react...

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Abstract

Disclosed is a pylorus screw bacterium fenestra element having adhesion function, characterized in that it comprises, (1) nucleic acid sequence represented by sequence No.1, (2) nucleic acid sequence corresponding to sequence in (1) within the genetic code degeneracy range, or (3) nucleic acid sequence hybridizing with sequence in (1) or / and (2) under strict conditions.

Description

technical field [0001] The invention relates to a Helicobacter pylori porin with adhesion function. Background technique [0002] Helicobacter pylori (Hp) infection is the main cause of chronic gastritis and peptic ulcer, and is also closely related to the occurrence of gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. In addition, serum epidemiological studies have shown that Hp infection is also related to the occurrence of circulation, respiratory, gastroduodenal and extradigestive system diseases and autoimmune diseases. With the rise of the etiological status of Hp, the research on its pathogenic mechanism is also in-depth. The pathogenic mechanism of Hp includes many links, but its adhesion mechanism is the most critical, because Hp must first be colonized in the human gastric mucosa to further play its role. Pathogenicity, and adhesion is the prerequisite for Hp colonization on the gastric mucosal surface. [0003] Sever...

Claims

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Application Information

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IPC IPC(8): C12N15/31C07H21/04C07K14/195C07K16/12A61K39/395A61K38/16A61P1/04A61P31/04
Inventor 白杨张亚历王继德陈烨赖卓胜林焕健张振书周殿元
Owner NAN FANG HOSPITAL