Implantable pouch seeded with insulin-producing cells to treat diabetes
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of cells and islets, applied in the field of implantable porous capsules
Inactive Publication Date: 2008-07-23
LIFESCAN INC
View PDF4 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
A limitation of this method is that the transplanted Sertoli and islet cells are not physically confined to the transplantation site
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0050] Example 1: Preparation of an implantable capsule
[0051] Polymer solutions are prepared to be lyophilized in capsules. The polymer used to generate the foam component was a copolymer of 35% PCL and 65% PGA (35 / 65 PCL / PGA) produced by Birmingham Polymers Inc. (Birmingham, AL), measured in HFIP at 30°C. The I.V. of the polymer was 1.79 dL / g. 1,4-dioxane / (35 / 65PCL / PGA) was weighed in a weight ratio of 95 / 5. The polymer and the solvent were placed in a flask, placed in a water bath at 70° C. and stirred for 5 hours in sequence. The solution was filtered with an extraction cannula (ultra-large pore size, model ASTM170-220 (EC)) and stored in a flask.
[0052] A mesh made of a reinforced mesh material knitting (code VKM-M) formed from a 90 / 10 copolymer of polyglycolic acid / polylactic acid (PGA / PLA) was ironed using a die-casting die at 80° C. for 2 minutes. After preparing the mesh, 0.4 mm spacers were placed on each end of the 15.3 x 15.3 cm aluminum mold and the two me...
Embodiment 2
[0054] Example 2: Preparation of an implantable capsule
[0055] A biodegradable capsule was prepared as described in Example 1, except that Textile Vicryl (code VWM-M) used a reinforcement mesh formed from a 90 / 10 copolymer of polyglycolic acid / polylactic acid (PGA / PLA) shape material.
Embodiment 3
[0056] Example 3: Preparation of an implantable capsule
[0057] A biodegradable bladder was prepared as described in Example 1, except that a woven reinforced mesh material was used, which was formed from 100% PDS.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
An implantable pouch and methods for implanting cells or cellular matter in mammals, comprising reinforced porous foam and a lumen. The lumen contains an insert that may or may not be removed prior to transplantation. The lumen may be loaded with at least one cell type expressing at least one transcription factor characteristic of a mammalian pancreatic beta cell.
Description
technical field [0001] The present invention relates to implantable capsules seeded with insulin secreting cells for the treatment of diabetes. In particular, the present invention provides an implantable porous capsule containing an opening for loading insulin secreting cells for treating diabetes, which opening can then be closed, if desired, sealed. Background technique [0002] Pancreatic tissue consists of three parts: exocrine, endocrine, and ducts. The endocrine pancreas includes islet cells responsible for the secretion of four specialized hormones. Such islets are composed of four distinct cell types: alpha, beta, delta, and polypeptide cells, which produce glucagon, insulin, somatostatin, and pancreatic polypeptide, respectively. According to the prior art involving the identification of endocrine cells, several key transcription factors important in β-cell development have been identified, including Pdx1, Ngn3, Hlxb9, Nkx6, Isl1, Pax6, Neurod, Hnfla, Hnf6 and oth...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more