The invention relates to parasite-expelling sterilization tablets and a preparation method of the parasite-expelling sterilization tablets. The tablets are prepared from the following medicinal materials in parts by weight: 20-40 parts of aloe, 15-35 parts of rhizoma coptidis, 15-30 parts of fructus ulmi, 15-25 parts of cumin, 12-24 parts of dark plum fruits, 12-22 parts of pericarpium zanthoxyli, 10-22 parts of the fruits of rangoon creeper, 10-20 parts of szechwan chinaberry fruits, 8-18 parts of gemma agrimoninae, 8-16 parts of frankincense, 7-15 parts of semen torreya, 7-14 parts of magnolia flowers, 6-13 parts of calculus bovis, 6-12 parts of semen raphani, 6-12 parts of leaves of purpleflower holly, 4-10 parts of Chinese brake herb, 3-9 parts of fructus bruceae, 3-9 parts of semen alpiniae katsumadai, 2-8 parts of fructus citri sarcodactylis, 1-6 parts of Chinese honey locust, and 1-5 parts of radix phytolaccae. The parasite-expelling sterilization tablets provided by the invention can effectively kill the intestinal parasite including hookworms, roundworms, whipworms, pinworms and the like in the body, and also have the efficacies of treating malnutritional stagnation and hernia swelling pain, and expelling toxins.