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Rough gentian soft capsule for treating hepatic diseases

A technology of soft capsules and gentian, applied in capsule delivery, antiviral agents, medical preparations containing active ingredients, etc., can solve problems such as poor water solubility, influence of blood drug concentration, poor absorption, etc.

Inactive Publication Date: 2008-08-13
北京罡吉医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the gentian extract is used as an intermediate extract to make a common solid oral preparation, due to its poor water solubility, the absorption after oral administration is poor, thereby affecting the blood drug concentration, and it is difficult to achieve the expected clinical efficacy

Method used

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  • Rough gentian soft capsule for treating hepatic diseases
  • Rough gentian soft capsule for treating hepatic diseases
  • Rough gentian soft capsule for treating hepatic diseases

Examples

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Effect test

preparation example Construction

[0039] (Preparation of Gentian Extract)

[0040] Such as figure 1 As shown in the given process flow chart, the extraction method of the gentian extract of the present invention includes the following steps: crushing→ethanol extraction→concentration→resin column chromatography→water washing→alcohol washing→vacuum decompression concentration→spray drying. Specifically, the gentian coarse powder (dried root) is extracted twice with 70% ethanol, the first time is added with 8 to 15 times the amount of ethanol, extracted for 2 hours, and the second time is added with 5 to 10 times the amount of ethanol, Extract for 1 hour, combine the ethanol extracts, reclaim the ethanol under reduced pressure until every liter of medicinal solution contains 0.3-0.5kg of crude drug, and put it on an AB-8 (or SP825) macroporous adsorption resin column (the amount of drug (weight) on the column and the amount of resin ( The ratio of volume) is 1~5:3~10 (W:V)), rinse with water to remove water-solu...

Embodiment 1

[0050] Component Weight (g / grain)

[0051] Gentian extract 0.1

[0052] soybean oil 0.4

[0053] Soy lecithin 0.008

[0054] Gelatin 0.25

[0055] Glycerin 0.085

[0056] Red iron oxide 0.0038

[0057] Parabens 0.002

Embodiment 2

[0059] Component Weight (g / grain)

[0060] Gentian extract 0.2

[0061] Corn oil 0.8

[0062] Lecithin 0.016

[0063] Gelatin 0.20

[0064] Glycerin 0.07

[0065] Benzoic acid 0.001

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Abstract

The disclosed soft capsule preparation comprises Chinese gentian extractive and medicinal adjuvant, the active constituents of the Chinese gentian extractive includes gentiopicrin, while the medicinal adjuvant includes deflocculating agent and suspension auxiliary agent. The capsule shell is prepared mainly from gelatin and glycerine. The medicament granule is prepared through a pressing process.

Description

technical field [0001] The invention relates to a longdan soft capsule for treating liver diseases. Background technique [0002] Gentiana is a plant of the Gentianaceae Gentiana genus, which has the functions of clearing away heat and dampness, and purging liver and gallbladder fire. In China, gentian-based traditional Chinese medicine compound has achieved good results in the treatment of acute and chronic liver diseases. The main component of Gentiana is gentiopicroside, and studies have found that gentiopicroside can be used to treat acute icteric hepatitis and chronic active hepatitis. The patent application with application number 01126701 discloses a traditional Chinese medicine preparation containing total gentian picrosides, a preparation method and the application of the preparation as a medicine for treating liver diseases. Formulations such as capsules. However, after the gentian extract is used as an intermediate extract to make a common solid oral preparatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/515A61K9/48A61K125/00A61P1/16A61P31/12
Inventor 张健刚
Owner 北京罡吉医药科技有限公司
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