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Compound preparation for dissolving staphyloase and preparation method

A lysostaphin enzyme and preparation technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of large toxic and side effects, narrow bactericidal spectrum, and easy generation of drug resistance, etc. Strong killing effect, broad bactericidal spectrum, high bactericidal activity and stability

Inactive Publication Date: 2009-01-14
SHANGHAI HI TECH BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to provide a compound preparation of lysostaphin and its preparation method to solve the shortcomings of the bactericides in the prior art that have a narrow bactericidal spectrum, large toxic and side effects, and easy to produce drug resistance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Manufacture 100 grams of lysostaphin complex enzyme preparation

[0056] Proportion:

[0057] Lysostaphin 0.001g

[0058] Lysozyme 53g

[0059] Chlorhexidine acetate 1g

[0060] Potassium phosphate 8g

[0061] Sodium chloride 12g

[0062] Chitin 25.9g

[0063] Method: In a sterile room, weigh each component according to the above table, add them in proportion to a clean glass or stainless steel container, stir gently, mix well, and fill them in plastic or glass bottles , stored in storage, and stored at room temperature.

[0064] The ratio can be used to manufacture skin and mucous membrane bactericidal drugs, and the additive dosage is 1-20%. Adding the skin and mucous membrane bactericidal drug in this ratio can kill gonorrhea, Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, Escherichia coli, etc. on the skin and mucous membrane surface within 2-10 minutes, with a killing rate of 99.9%. . It can treat abscesses, psoriasis, ulcers, bedsores, b...

Embodiment 2

[0066] Manufacture 100 grams of lysostaphin complex enzyme preparation

[0067] Proportion:

[0068] Lysostaphin 0.01g

[0069] Lysozyme 52g

[0070] Sodium Benzoate 1g

[0071] Potassium phosphate 9g

[0072] Sodium chloride 12g

[0073] Chitosan 26g

[0074] Method: In a sterile room, weigh each component according to the above table, add them in proportion to a clean glass or stainless steel container, stir gently, mix well, and fill them in plastic or glass bottles , stored in storage, and stored at room temperature.

[0075] This ratio is used for food preservation, and the additive amount is 1-20%.

[0076] Adding the food with this ratio can prolong the shelf life of fresh food, and can prolong the shelf life of milk and seafood.

Embodiment 3

[0078] Manufacture 100 grams of lysostaphin complex enzyme preparation

[0079] Proportion:

[0080] Lysostaphin 0.1g

[0081] Lysozyme 52g

[0082] Antimicrobial peptide 1g

[0083] Potassium phosphate 9g

[0084] Sodium chloride 12g

[0085] Chitosan 25.9g

[0086] Method: In a sterile room, weigh each component according to the above table, add them in proportion to a clean glass or stainless steel container, stir gently, mix well, and fill them in plastic or glass bottles , stored in storage, and stored at room temperature.

[0087] The proportioning is used to make oral drug additives with a dosage of 1-40%. Adding the oral medicine with this ratio can treat various oral diseases, respiratory diseases and acute and chronic gastritis caused by bacterial infection.

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PUM

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Abstract

The present invention discloses a lysostaphin compounded preparation. Said preparation comprises bacteria-killing effective quantity of lysostaphin and lysozyme. Said lysostaphin compounded preparation has higher bacteria-killing effect as compared with single lysostaphin, not only has the strong bacteria-killing action for Gram-positive bacterium and Gram-negative bacterium, but also has the good effect for killing the fungi of Candida albicans and red trichophyton, etc. It has high bacteria-killing activity and stability, does not produce drug resistance, and has no toxic side effect.

Description

technical field [0001] The invention relates to a biological bactericidal preparation, in particular to a compound preparation of lysostaphin and a preparation method thereof. Background technique [0002] At present, clinical bacterial infection is quite serious, and it has become a major killer threatening human health in the past 20 years. Moreover, an increasing number of bacteria are resistant to antibiotic treatment, posing a serious threat to public health. In the United States, more lives were lost to drug-resistant bacterial infections in 1998 than in Vietnam. Germs that were once easily killed by antibiotics, such as Staphylococcus aureus, Pneumococcus pneumococcus, Pseudomonas aeruginosa, Candida albicans, Escherichia coli, etc., are now becoming more and more fierce due to the emergence of drug resistance, making people more and more serious. More and more helpless. Among them, drug-resistant Staphylococcus aureus is the most active molecule. The infection cau...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/43A61P31/04
Inventor 陆婉英黄青山
Owner SHANGHAI HI TECH BIOENG
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