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Method for preparing chitosan or/and gelatin-polylacticacid polymer blend three-dimensional porous stent

A three-dimensional porous chitosan technology, applied in medical science, prosthesis, etc., can solve the problems of uneven structure and difficult stability of the blend, and achieve strong connectivity, good biocompatibility and degradability, Effects from a wide range of sources

Inactive Publication Date: 2009-01-14
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this preparation method is that the blend is not easy to maintain stability, and the structure is uneven after drying

Method used

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  • Method for preparing chitosan or/and gelatin-polylacticacid polymer blend three-dimensional porous stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Add 1.8182g of poly DL-lactic acid into 16ml of chloroform, stir to dissolve it. After the dissolution is complete, add 0.0606g chitosan and 0.1212g gelatin and mix well. Add 4g of sodium polyphosphate and 4g of sodium chloride and stir evenly, wherein the particle size range of sodium polyphosphate and sodium chloride is between 50 and 200 microns. When the chloroform is volatilized until the system becomes viscous, the mixed system is cast into a preset hydrophobized glass mold for molding. The molded solid was taken out from the mold, put into a vacuum drying oven, and further dried at room temperature and 0.1 MPa for 48 hours. The solid was taken out, placed in an acetic acid solution with a mass concentration of 2%, and gently shaken at a constant temperature for 96 hours at a temperature of 37°C. The solid was taken out and placed in deionized water. After repeated washing for 20 times, no sodium chloride was detected in the washed deionized water, and a wet ste...

Embodiment 2

[0018] Add 0.6667 g of poly-L-lactic acid to 9 ml of dichloromethane, and stir to dissolve it. After the dissolution is complete, add 0.1111g chitosan and 0.2222g gelatin, and mix well. Add 4g of sodium polyphosphate and 4g of potassium chloride and stir evenly, wherein the particle size range of sodium polyphosphate and potassium chloride is between 50 and 200 microns. When the dichloromethane volatilizes until the system becomes viscous, the mixed system is cast into a preset hydrophobized glass mold for molding. The molded solid was taken out from the mold, put into a vacuum drying oven, and further dried at room temperature and 0.1 MPa for 24 hours. Take out the solid, place it in a solution with a mass concentration of 1% acetic acid and a mass concentration of 5% sodium polyphosphate, and shake gently at a constant temperature for 48 hours under the condition of 37°C. The solid was taken out and placed in deionized water, and the water was changed every 12 hours. After...

Embodiment 3

[0020] Add 0.7692g of poly DL-lactic acid into 8ml of chloroform, and stir to dissolve it. After the dissolution is complete, add 0.2308g chitosan and mix well. Add 2g of sodium polyphosphate and 2g of sodium chloride and stir evenly, wherein the particle size range of sodium polyphosphate and sodium chloride is between 50 and 200 microns. When the chloroform is volatilized until the system becomes viscous, the mixed system is cast into a preset hydrophobized glass mold for molding. The molded solid was taken out from the mold, put into a vacuum drying oven, and further dried at room temperature and 0.06MPa for 24 hours. Take out the solid, place it in a solution with a mass concentration of 2% acetic acid and a mass concentration of 4% sodium polyphosphate, and shake gently at a constant temperature for 48 hours under the condition of 37°C. The solid was taken out and placed in deionized water, and the water was changed every 12 hours. After repeated washing for 10 times, t...

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Abstract

The present invention discloses a preparation method of chitosan or / and gelatin-polylactic acid blend three-dimensinal multiporous scaffold, belonging to the field of tissue engineering scaffold preparation technology. Said method includes the following steps: dissolving the polylactic acid in dichloromethane, chloroform or tetrahydrofuran; adding chitosan or gelatin or blend of both the, sodium polyphosphate and sodium chloride or potassium chloride, stirring them and uniformly mixing them; pouring them into mould and forming; vacuum drying and placing the above-mentioned material into a mixed solution of acetic acid solution or acetic acid and sodium polyphosphate for several days, taking out said material and placing said material in deionized water to remove pore-forming agent; drying so as to obtain the invented scaffold.

Description

technical field [0001] The invention relates to a preparation method of a chitosan-gelatin-polylactic acid blend three-dimensional porous scaffold, which belongs to the tissue engineering scaffold preparation technology. Background technique [0002] Polylactic acid is a synthetic polymer material widely used in tissue engineering scaffold materials. It has the advantages of good biocompatibility, degradability, and easy molding, but it also has the disadvantages of poor hydrophilicity, poor cell adhesion and proliferation. Both chitosan and gelatin are valuable natural polymers with good biocompatibility and safety, and are widely used in biomedical fields. But when it is used for load-bearing tissue repair, its mechanical properties often cannot meet the requirements. Therefore, the preparation of new scaffold materials by combining the two materials can make full use of the excellent mechanical properties of polylactic acid and the biocompatibility of chitosan or / and gel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/18A61L27/20
Inventor 姚芳莲于潇张彬姚康德
Owner TIANJIN UNIV
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