Magnetic target slow-release catopril and its preparing method

A captopril and sustained-release technology, which is applied in the field of magnetically targeted sustained-release captopril and its preparation, can solve the problems of preparing captopril sustained-release preparations that have not been described or mentioned, etc. To achieve the effect of reducing dosage, enhancing specificity and improving curative effect

Inactive Publication Date: 2009-06-10
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The literature (Abubakr O.Nur, Jun S.Zhang, Int.J.Pharm.194(2000)139-146) comprehensively discusses the progress of captopril's controlled release, but does not mention the use of external magnetic substances to release Improving the therapeutic effect of drugs; at the same time, there is no explanation for the preparation of captopril sustained-release agent with acid-soluble inorganic material hydrotalcite as carrier

Method used

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  • Magnetic target slow-release catopril and its preparing method
  • Magnetic target slow-release catopril and its preparing method
  • Magnetic target slow-release catopril and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Add 3.0795g of Mg(NO 3 ) 2 ·6H 2 O and 2.2507g of Al(NO 3 ) 3 9H 2 O is made into the mixed salt solution A that Mg / Al molar ratio is equal to 2 with 50ml water; In addition, the NaOH of 1.5g and the former drug of captopril of 2.6097g are made into mixed alkali solution B with 150ml water, and then 0.0576g of MgFe 2 o 4 put into it;

[0032] 2. In N 2 Slowly drop the mixed salt solution A into the vigorously stirred mixed alkali solution B under protection, and stop adding when the pH value is around 10;

[0033] 3. The obtained slurry was crystallized at 25° C. for 48 hours, suction filtered, washed, and vacuum-dried at room temperature for 72 hours to obtain a magnetic captopril sustained-release preparation. The water used in the process is decarbonized deionized water.

[0034] figure 1 Cpl-LDHs / MgFe 2 o 4 X-ray powder diffraction characterization results, with the crystal structure of hydrotalcite-like materials.

[0035] figure 2 Cpl-LDHs / MgFe...

Embodiment 2

[0039] MgFe in embodiment 1 step 1 2 o 4 Use NiFe 2 o 4 Instead, other parts are the same as in Example 1.

[0040] The sample obtained is analyzed in the same manner as in Example 1, and its empirical chemical formula is: [Mg 0.632 al 0.368 (OH) 2 ](C 9 h 14 NO 3 S 2- ) 0.0736 (CO 3 2- ) 0.1104 0.6H 2 O / (NiFe 2 o 4 ) 0.0152 , the content of captopril is 20.40%, and the specific saturation magnetization is 1.30emu / g.

Embodiment 3

[0042] MgFe in embodiment 1 step 1 2 o 4 with Fe 3 o 4 Instead, other parts are the same as in Example 1.

[0043] The sample obtained is analyzed in the same manner as in Example 1, and its empirical chemical formula is: [Mg 0.642 al 0.358 (OH) 2 ](C 9 h 14 NO 3 S 2- ) 0.0667 (CO 3 2- ) 0.1123 0.8H 2 O / (Fe 3 o 4 ) 0.0194 , the content of captopril is 21.72%, and the specific saturation magnetization is 3.64emu / g.

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Abstract

The present invention relates to a magnetic target slowly-released captopril and its preparation method. Said invention uses spinel type ferrite and tri-iron tetroxide as magnetic material seed, uses anionic lamellar material LDHs as main body and uses captopril as intercalation guest, and utilizes self-assembling method to implement structure design of Cpl-LDHs / MP. Said magnetic captopril slow-release agent is shell-kernel structure, namely, the exterior of magnetic nano granule is covered with lamellar material Cpl-LDHs, specific saturated magnetization is 1.0-6.0 emu / g, its granular grain distribution is 20-200 nm, its captopril content in said slow-release preparation is 10-50%, and its slowly-released effective time can be up to 0.4h-13h.

Description

Technical field: [0001] The invention relates to a magnetically targeted sustained-release captopril and a preparation method thereof. Background technique: [0002] In the process of clinical treatment of diseases, it is often necessary to improve the targeting of drugs in order to maximize the efficacy of drugs and minimize the adverse reactions of drugs. Therefore, targeted drug delivery system has become a modern drug important content to learn. Targeted drug delivery system refers to the drug delivery system in which the drug is combined with the carrier or encapsulated by the carrier to directly locate the drug in the target area, or the drug is assembled in the target area after administration, so that the drug concentration in the target area is higher than that in normal tissues. Targeted drug delivery can reduce the dosage of drugs, improve the efficacy of drugs, reduce the side effects of drugs, and enhance the specificity of drugs to target tissues. The common ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61K31/401A61K31/555A61K9/00A61P9/12A61P9/04
CPCA61K9/5094A61K31/401A61P9/04A61P9/12
Inventor 段雪张慧孙辉
Owner BEIJING UNIV OF CHEM TECH
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