Process for separating and purifying different end group polymer using cyclic dextrin
A separation, purification and polymer technology, applied in the chemical industry, can solve the problems of complicated separation and purification, and achieve the effect of clear principle and wide application.
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Embodiment 1
[0018] Example 1: Separation and purification of polyethylene oxide derivatives (PEG, Mn=2000) whose terminal groups are respectively propionyloxy and carboxyl by α-cyclodextrin.
[0019] Step (a): Stirring at 25°C, add 0.376g (18.8mmol) aqueous solutions of polyethylene oxide derivatives (P2C3 and P2COOH) whose end groups are propionyloxy or carboxyl to α-cyclodextrin In the aqueous solution, use a spectrophotometer to record their turbidity, so as to reflect their recombination rate. figure 1 is the recorded compound rate curve. Then 0.376 g (18.8 mmol) of P2C3 and 0.376 g (18.8 mmol) of P2COOH were added to 50 mL of water (P2C3:P2COOH=1:1). After fully dissolving, this solution was added to an aqueous solution of α-cyclodextrin (3.76 g of α-cyclodextrin dissolved in 50 mL of water) at room temperature. Stirring was stopped after 6 hours, and a large amount of white precipitates precipitated out. Filtration and washing the product several times with water removes uncomple...
Embodiment 2
[0024] Example 2: Separation and purification of polyethylene oxide (PEG, Mn=2000) and polyethylene oxide derivatives (P2C6) whose end groups are hexanoyloxy groups using α-cyclodextrin.
[0025] Stirring at 25°C, add 0.376g (18.8mmol) of polyethylene oxide (PEG) and polyethylene oxide derivatives (P2C6) with hexanoyloxy-terminated aqueous solutions to the α-cyclopaste In the aqueous solution of the refined solution, their turbidity is recorded by a spectrophotometer, so as to reflect their recombination rate. Then 0.376 g (18.8 mmol) of PEG and 0.376 g (18.8 mmol) of P2C6 were added to 50 mL of water (PEG:P2C6=1:1). After fully dissolving, this solution was added to an aqueous solution of α-cyclodextrin (3.76 g of α-cyclodextrin dissolved in 50 mL of water) at room temperature. After stirring, a large amount of white precipitates appeared. After filtering, the product was washed with water several times to remove uncomplexed cyclodextrin and polymer. The obtained crystallin...
Embodiment 3
[0026] Example 3: Separation and purification of polyethylene oxide derivatives (PEG, Mn=6000) whose terminal groups are respectively propionyloxy and carboxyl by α-cyclodextrin.
[0027]Stir at 25°C, add 18.8mmol aqueous solutions of polyethylene oxide derivatives (P6C3 and P6COOH) whose end groups are propionyloxy or carboxyl groups to the aqueous solution of α-cyclodextrin, and use a spectrophotometer to measure Their turbidity is recorded, reflecting their rate of recombination. Then 18.8 mmol of P6C3 and 18.8 mmol of P6COOH were added to 50 mL of water (P6C3:P6COOH=1:1). After fully dissolving, this solution was added to an aqueous solution of α-cyclodextrin (3.76 g of α-cyclodextrin dissolved in 50 mL of water) at room temperature. After stirring, a large amount of white precipitates appeared. After filtering, the product was washed with water several times to remove uncomplexed cyclodextrin and polymer. The obtained crystalline complex was dissolved in 200 mL of water...
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