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Slow release preparation of Kui-Liu-Ping

A slow-release preparation and preparation technology, which is applied in the directions of inorganic inactive ingredients, non-active ingredients of polymer compounds, inactive ingredients of oil/fat/wax, etc., can solve the problems of short biological half-life, inconvenient use by patients, etc. Or the effect of improving adaptability and reducing the frequency of medication

Inactive Publication Date: 2007-07-25
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Quetiapine is a drug with a short biological half-life, which needs to be administered twice a day, which brings inconvenience to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of embodiment 1-quetiapine sustained-release tablet (1)

[0050] Method: Take 100 grams of quetiapine, 50 grams of hydroxypropyl cellulose, 15 grams of hypromellose, 10 grams of lactose, 10 grams of microcrystalline cellulose, 1 gram of carbomer, and 30 grams of polyethylene glycol 4000 , mixed evenly, dry granulated, mixed with magnesium stearate, and compressed into tablets to obtain a finished product with a drug content of 100mg / tablet. Then, the dissolution rate of the quetiapine sustained-release tablet (1) in 900 ml of water at 37° C. was measured. After release measurement, the results are shown in Table 1, which meets the requirements.

[0051] The dissolution rate of table 1 quetiapine sustained-release tablet (1)

[0052] Sampling time (hours)

Embodiment 2

[0053] The preparation of embodiment 2-quetiapine sustained release tablet (2)

[0054] Method: Take 100 grams of quetiapine, 10 grams of hydroxypropyl cellulose, 20 grams of stearyl alcohol, 15 grams of hypromellose, 1 gram of carbomer, and 10 grams of lactose, respectively, pass through 80 mesh sieves, grind and mix Evenly, add a 95% ethanol solution of 10% polyvinylpyrrolidone as a binder and stir to make a soft material, granulate through a 16-mesh sieve, dry the granules at room temperature for 2 hours, granulate with a 16-mesh sieve, and then add stearin Magnesium acid 4.5 grams, micropowder silica gel 2 grams, mix evenly, and tabletting obtains finished product, and containing medicine amount is 100mg / sheet. Then the dissolution rate of the quetiapine sustained-release tablet (2) in 900 ml of water at 37° C. was measured. After release measurement, the results are shown in Table 2, which meets the requirements.

[0055] The dissolution rate of tab...

Embodiment 3

[0057] The preparation of embodiment 3-quetiapine sustained release tablet (3)

[0058] Method: Take 100g of quetiapine, 35g of hypromellose, 5g of microcrystalline cellulose, and 1g of carbomer respectively, pass through 80 mesh sieves, mix well, and add 95% ethanol solution of polyvinylpyrrolidone with a concentration of 10% Used as a binder and stirred to make a soft material, granulated through a 16-mesh sieve, dried at 60°C for 1 hour, granulated with a 16-mesh sieve, then added with 2.5 grams of magnesium stearate, mixed evenly, and pressed into tablets to obtain a finished product, containing drugs The dosage is 100mg / tablet. Then the dissolution rate of the quetiapine sustained-release tablet (3) in 900 ml of water at 37° C. was measured. After release measurement, the results are shown in Table 3, meeting the requirements.

[0059] The dissolution rate of table 3 quetiapine sustained release tablet (3)

[0060] Sampling time (hours)

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PUM

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Abstract

A slowly-released medicine of quinthiopine in the form of dispersing solid is prepared from quinthiopine and slow-releasing skeleton.

Description

[0001] [Technical Field] The present invention relates to a sustained-release preparation of quetiapine and a preparation method thereof. [Background technique] [0002] The research and development of sustained-release preparations has a history of more than 40 years. It releases slowly and at a non-constant rate as required in a prescribed environment. Prolonged formulation. This kind of preparation can make the human body maintain this kind of blood drug concentration for a long time, instead of dropping rapidly like ordinary preparations, so as to avoid the "peak and valley" phenomenon that occurs when common preparations are frequently administered, and ensure the safety of the drug. Sexuality, effectiveness or adaptability have been improved, thereby reducing the number of medications, which greatly facilitates patients, especially patients who have been taking medication for a long time. Commonly used oral dosage forms include matrix tablets, microporous coated surface...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/48A61K47/02A61K47/12A61K47/34A61K47/38A61K47/42A61K47/44A61K31/554A61P25/18A61K47/10
Inventor 刘凤鸣
Owner 刘凤鸣