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Traditional Chinese medicine composition for treating cerebrovascular disease, and its preparing method

A technology for cerebrovascular diseases and compositions, which is applied in the field of traditional Chinese medicine injections for the treatment of cerebrovascular diseases and its preparation, can solve the problems of large toxic and side effects, poor effect, etc., achieve rapid onset of action, less ingredients in the formula, and advanced production technology Effect

Active Publication Date: 2007-07-25
JIANGSU SHENLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, such diseases are generally treated with chemical drugs, but the effect is not good and the side effects are relatively large. Most of the drugs have problems in effectiveness and safety, and there is still a lack of drugs that have significant effects, long-term curative effects, and are safe to use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Get 10kg of gardenia medicinal material coarse powder, reflux extraction with 50% ethanol 50kg for 3 times, each time for 2 hours, filter, combine the extracts, concentrate the extracts to a relative density of 1.10 (60°C), add 50kg of water, let stand, Filtrate, concentrate the filtrate, put the sample on an activated carbon adsorption column, elute with 10kg of water first, then elute with 50kg of 30% ethanol, collect the 30% ethanol eluate, concentrate, refrigerate at 0-5°C, and filter to obtain Precipitate, and dry the precipitate to obtain 284.2 g of gardenia extract. The content of geniposide in the Gardenia jasmine extract was determined by the method of content determination in the quality standard: 58.22%.

Embodiment 2

[0059] Get 10 kg of gardenia medicinal material coarse powder, reflux extraction with 70 kg of 60% ethanol for 3 times, each time for 2 hours, filter, combine the extracts, concentrate the extracts to a relative density of 1.10 (60 ° C), add 70 kg of water, let stand, Filtrate, concentrate the filtrate, put the sample on an activated carbon adsorption column, elute with 20kg of water first, then elute with 60kg of 40% ethanol, collect the 40% ethanol eluate, refrigerate at 0-5°C after concentration, and filter to obtain a precipitate , and dried the precipitate to obtain 264.8 g of Gardenia extract. The content of geniposide in the Gardenia jasminoides extract was determined by the method of content determination in the quality standard: 65.81%.

Embodiment 3

[0061] Get gardenia medicinal material coarse powder 10kg, reflux extraction with 70% ethanol 80kg 3 times, each time 2 hours, filter, combine extract solution, concentrate extract solution to be 1.10 (60 ℃) of relative density, add 80kg water, let stand, Filtrate, concentrate the filtrate, put the sample on an activated carbon adsorption column, elute with 20kg of water first, then elute with 70kg of 50% ethanol, collect the 50% ethanol eluate, concentrate, refrigerate at 0-5°C, and filter to obtain Precipitate, and dry the precipitate to obtain 240.1 g of gardenia extract. The content of the extract is determined by the method of content determination in the quality standard, and the content of geniposide in the Gardenia jasmine extract is: 75.95%.

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PUM

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Abstract

A Chinese medicine for treating cerebrovascular disease contains iridoid glycoside (1-14 Wt portions) extracted from capejasmine fruit, and erigerontis flavone (1-2) extracted from fleabane herb. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cerebrovascular diseases and a preparation method thereof, in particular to a traditional Chinese medicine injection for treating cerebrovascular diseases and a preparation method thereof. Background of the invention [0002] Cerebrovascular disease is a worldwide common disease, which is characterized by high morbidity, high mortality, and high disability rate. At present, such diseases are generally treated with chemical drugs, but the effect is not good and the side effects are relatively large. Most of the drugs have problems in effectiveness and safety, and there is still a lack of drugs that have significant effects, long-term curative effects, and are safe to use. . [0003] Gardenia is the dry ripe fruit of Rubiaceae gardenia [Gardenia jasminoides Ellis]. This product is cold in nature, bitter in taste, and returns to the Heart, Lung, and Sanjiao meridians. Effi...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/744A61P9/10
Inventor 胡传良
Owner JIANGSU SHENLONG PHARMA
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