Compound ofloxacin injection and its preparation method

A preparation technology of compound ofloxacin and injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of weakened effect of common drugs and drug resistance of virus strains , to achieve rapid and significant curative effect, high bioavailability, and wide clinical application

Inactive Publication Date: 2007-08-01
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For a long time, due to the overuse of antibiotics, virus strains have become more and more resistant, and common drugs have gradually become less effective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 (every part is 500g):

[0016] Compound ofloxacin injection: 5 parts of ofloxacin, 15 parts of colistin sulfate, 150 parts of propylene glycol, and 1 part of trimethoprim.

[0017] Made in the following way:

[0018] (1) Get 5 parts of ofloxacin, 15 parts of colistin sulfate, 150 parts of propylene glycol, and 1 part of trimethoprim by weight;

[0019] (2) Add 15 parts of colistin sulfate to 400 parts of water for injection, stir for 10 minutes until clear, then add 5 parts of ofloxacin, and adjust the pH to pH 4.0-4.3 with 10% sulfuric acid solution to make the solution clear;

[0020] (3) Heat 150 parts of propylene glycol to 75°C, add 1 part of trimethoprim and stir to dissolve;

[0021] (4) Combine the solution prepared by step (2) and step (3), stir and add water for injection to 1000 parts after clarification, a kind of compound ofloxacin injection is made.

Embodiment 2

[0022] Embodiment 2 (every portion is 1500g):

[0023] Compound ofloxacin injection: 10 parts of ofloxacin, 25 parts of colistin sulfate, 300 parts of propylene glycol, and 1.5 parts of trimethoprim.

[0024] is made in the following way:

[0025] (1) Get 10 parts of ofloxacin, 25 parts of colistin sulfate by weight, 300 parts of propylene glycol and 1.5 parts of trimethoprim;

[0026] (2) Add 25 parts of colistin sulfate to 400 parts of water for injection, stir for 15 minutes until clear, then add 10 parts of ofloxacin, and adjust the pH with 10% sulfuric acid solution until the solution is clear to pH 4.0-4.3;

[0027] (3) 300 parts of propylene glycol were heated to 85°C, and 1.5 parts of trimethoprim were added;

[0028] (4) Combine the solution prepared by step (2) and step (3), stir and add water for injection to 1000 parts after clarification, a kind of compound ofloxacin injection is made.

Embodiment 3

[0029] Embodiment 3 (every part is 1000g):

[0030] Compound ofloxacin injection: 20 parts of ofloxacin, 5 parts of colistin sulfate, 50 parts of propylene glycol, and 20 parts of trimethoprim.

[0031] Made in the following way:

[0032] (1) Get 20 parts of ofloxacin, 5 parts of colistin sulfate by weight, 50 parts of propylene glycol, 20 parts of trimethoprim;

[0033] (2) Add 5 parts of colistin sulfate to 400 parts of water for injection, stir for 20 minutes until clear, then add 20 parts of ofloxacin, and adjust the pH with 10% sulfuric acid solution until the solution is clear to pH 4.0-4.3;

[0034] (3) Heat 50 parts of propylene glycol to 75°C, add 20 parts of trimethoprim and stir to dissolve;

[0035] (4) Combine the solution prepared by step (2) and step (3), stir and add water for injection to 1000 parts after clarification, a kind of compound ofloxacin injection is made.

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PUM

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Abstract

The invention disclosed a kind of complex ofloxacin injection as well as preparing method. The injection contains 5-20 shares of ofloxacin, 5-25 shares of sulphuric acid colistin, 1-20 shares of trimethoprim and 50-300 shares of propylene glycol. The preparing procedure includes the following steps: (1) weighing materials; (2) putting the sulphuric acid colistin into injection water, stirring until it's all soluble; (3) heating propylene glycol to 75-85DEG C, adding trimethoprim, stirring to make it soluble; (4) putting together the solution of step (2) and (3), clarifying the solution, regulating the ph value of the solution, adding water to 1000 shares to get the preparation. Ofloxacin has the antibacterial activity of the third generation quinolones which can inhibit the bacteria prokaryotic cell DNA gyrase and DNA replication. Sulphuric acid colistin has no residue and side effects in animal bodies. The combination of the two medicines can widen the antibacterial spectrum and increase the curative effect.

Description

technical field [0001] The invention relates to the field of drug injections, in particular to a compound ofloxacin injection and a preparation method thereof. Background technique [0002] Piglet yellow and white scour is an acute and fatal infectious disease that often occurs in newborn piglets. It usually occurs within a few hours to three days after the birth of piglets, with high incidence and high mortality. The clinical manifestations are characterized by yellow or white loose feces and acute death of sick piglets. When one piglet becomes ill in a litter, it can spread rapidly to the whole litter. After the onset of piglets, if the comprehensive prevention and control measures are not taken in time, the whole litter of piglets will die; the loss is great, and this disease is extremely harmful to the pig industry. [0003] The antigenic structure of Escherichia coli that causes yellow and white scour of piglets is complex. According to the bacterial antigens (O antig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K31/5383A61K9/08A61K47/10A61P31/04A61P1/12A61K31/505
Inventor 魏宗生耿强斌郭建华
Owner TIANJIN SHENGJI GRP CO LTD
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