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Soluble mangiferin clathrate and its prepn

A mangiferin and clathrate technology, which is applied in the field of clathrate preparation, can solve problems such as unsatisfactory mangiferin absorption and difficult selection of mangiferin dosage forms

Inactive Publication Date: 2007-08-22
广西中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In research and practical application, it is found that the solubility of mangiferin in water (0.111mg / ml) is very small, and it is almost insoluble in water, which makes it difficult to choose the dosage form of mangiferin, and at the same time, it also makes the absorption of mangiferin in the body unsatisfactory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Mix 3.6g of hydroxypropyl-β-cyclodextrin with 120ml of water evenly, heat to 50°C, adjust the pH value to 8.5 with sodium hydroxide solution, add 1g of mangiferin fine powder, and add ethanol so that the volume content of alcohol is 5 %, stirred for 3 hours, filtered through a microporous membrane (Φ=0.22 μm), and the filtrate was taken and vacuum-dried to obtain the mangiferin inclusion compound.

Embodiment 2

[0019] Mix 3.6g of hydroxypropyl-β-cyclodextrin with 120ml of water evenly, heat to 85°C, adjust the pH value to 7.5 with sodium carbonate, add 1g of mangiferin fine powder, and add ethanol so that the volume content of alcohol is 25%. Stir for 7 hours, filter with ordinary filter, take the filtrate, and spray dry to obtain the mangiferin inclusion compound.

Embodiment 3

[0021] Mix 3.6g of hydroxypropyl-β-cyclodextrin with 120ml of water evenly, heat to 45°C, adjust the pH value to 10 with potassium hydroxide, add 1g of mangiferin fine powder, and add ethanol so that the volume content of alcohol is 85% , stirred for 10 hours, filtered through a microporous membrane (Φ=0.22 μm), the filtrate was taken, concentrated under reduced pressure, and dried below 100° C. to obtain the mangiferin inclusion compound.

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PUM

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Abstract

The present invention relates to one kind of mangiferin clathrate with high water solubility and it preparation process. Normally mangiferin is water insoluble, and the present invention solves the problem by means of clathrating technology to form mangiferin clathrate with water solubility as high as 35.99 mg / ml.

Description

technical field [0001] The present invention relates to an inclusion compound of active ingredients of traditional Chinese medicine, and a preparation method of the inclusion compound; especially after molecular inclusion of mangiferin and hydroxypropyl-β-cyclodextrin (HP-β-CD) The clathrate formed. Background technique [0002] Mangiferin can be extracted from mango leaves, almond leaves, Anemarrhena and other plants. It has been reported in the literature that mangiferin has a wide range of pharmacological effects: Yu Shengmin and Zhong Ming of Guangxi National Medical Research Institute reviewed some of the medicinal mechanisms of mangiferin in the "Progress in Pharmacological Research of Mangiferin" published in "China Traditional Chinese Medicine Science and Technology" 1999, 6 (3). It is pointed out that mangiferin (mangiferin) is a carbon glycoside of tetrahydroxypyrrole, which belongs to the compound of biphenylpyrrole. Modern pharmacology and clinical research have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K47/40A61P9/00A61P29/00A61P25/00A61P31/00
Inventor 王志萍邓家刚李学坚王勤
Owner 广西中医学院
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