Use of Rhizoma-paridis alcohol extract for inhibiting blood-vessel generation

An angiogenesis, alcohol extraction technology, applied in the directions of plant/algae/fungus/moss components, drug combinations, plant raw materials, etc., can solve the problem of high cost, anti-angiogenesis therapy for malignant tumors can not be widely and practical clinical application, High price and other problems, to achieve the effect of low price, inhibition of endothelial cell DNA synthesis, and inhibition of proliferation

Inactive Publication Date: 2007-08-29
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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  • Abstract
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Problems solved by technology

However, the existing angiogenesis inhibitors, such as Avastin and Endostatin, are extremely expensive and unaffordable to the vast majority of ca

Method used

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  • Use of Rhizoma-paridis alcohol extract for inhibiting blood-vessel generation
  • Use of Rhizoma-paridis alcohol extract for inhibiting blood-vessel generation
  • Use of Rhizoma-paridis alcohol extract for inhibiting blood-vessel generation

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Experimental program
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Embodiment Construction

[0026] Chonglou is a natural Trilliaceae (Trilliaceae) plant, also known as seven-branched lotus and unicorn lotus, distributed in Yunnan, Guangxi and other places.

[0027] 1.1 Extraction of the alcoholic extract of Chonglou

[0028] After drying the rhizome of Chonglou in an oven at 60°C for 6 hours, pulverize it, and weigh 100g. After putting the medicinal powder in the flask, add 800ml of 80% alcohol to soak for 30 minutes, heat to boiling, and maintain for 2 hours. Store at 4°C after filtration. Take 800ml of 80% alcohol, add it to the medicinal residues and repeat the above extraction operation twice. Mix the medicinal liquid filtered out three times, pour the medicinal liquid into an evaporating dish to volatilize, let it evaporate to dryness, calculate the yield, and prepare the drug concentration according to the yield.

[0029] 1.2 The in vitro proliferation experiment of the alcohol extract of Chonglou on human umbilical vein endothelial cells and human intestina...

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Abstract

The present invention relates to a paris polyphylla alcohol extract and its application for inhibiting vascularization. It is characterized by that the preparation method of paris polyphylla alcohol extract includes the following steps: drying root and stem of paris polyphylla, pulverizing, soaking the pulverized root and stem of paris polyphylla in ethyl alcohol whose concentration is 80%, heating and boiling, filtering so as to obtain the paris polyphylla alcohol extract. Said invention also provides the application method for inhibiting vascularization by using said paris polyphylla alcohol extract.

Description

technical field [0001] The present invention relates to a kind of alcoholic extract of Chonglou, in particular to the application of the alcoholic extract of Chonglou for inhibiting angiogenesis. Background technique [0002] Tumor growth and metastasis rely on new blood vessels to provide nutrition and metastasis channels. Inhibiting tumor angiogenesis is closely related to blocking tumor occurrence, development, invasion and metastasis. [0003] Before the present invention, anti-angiogenesis therapy for malignant tumors has brought new hope to patients with refractory and drug-resistant tumors since the VEGF monoclonal antibody was approved for FDA application. However, the existing angiogenesis inhibitors, such as Avastin and Endostatin, are unaffordable to the vast majority of cancer patients in my country because of their extremely high cost, so that the anti-angiogenesis therapy for malignant tumors cannot be widely and practically applied clinically. Contents of t...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P35/00A61K125/00
Inventor 钱晓萍刘宝瑞胡静
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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