Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing d-2 amino-butyl-alcohol-1

A technology of aminobutanol and its manufacturing method, which is applied to the preparation of aminohydroxyl compounds, chemical instruments and methods, and the preparation of organic compounds, etc. It can solve the problems of three wastes and the lack of pharmacological activity of the left-handed form, and achieve the effect of reducing production costs

Inactive Publication Date: 2007-08-29
上海五洲同一药业有限公司
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Hexaminobutanol is an important raw material for medicine and chemical industry. It is split into dextrorotary and levorotatory forms. Due to its lack of pharmacological activity, the levorotatory form has no practical application reports and has become "three wastes" in industry.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] High-pressure racemization When the reaction temperature is 175°C, the reaction pressure is 20Mpa, and the optical rotation of L-aminobutanol is -9.00°, the optical rotation of dextroaminobutanol is -0.5°, and the yield is 80-85%.

Embodiment 2

[0015] High-pressure racemization When the reaction temperature is 172°C and the reaction pressure is 20Mpa, when the optical rotation of levo-aminobutanol is -9.00°, the optical rotation of dextroaminobutanol is -0.6°, and the yield is 80-85%.

Embodiment 3

[0017] High-pressure racemization When the reaction temperature is 178°C and the reaction pressure is 20Mpa, when the optical rotation of L-aminobutanol is -9.00°, the optical rotation of dextroaminobutanol is -0.5°, and the yield is 82%.

[0018] Existing once used various raw materials such as cobalt thorium, cobalt rhodium, cobalt iron, cobalt manganese etc. to prepare catalyzer, its effective racemic L-aminobutanol per kilogram of catalyzer is 100KG, and the present invention adopts cobalt as raw material, makes every kilogram of catalyzer The effective racemic L-aminobutanol has been increased to 800 kg.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a manufacturing method for a d-2-amino group butyl alcohol that transforms left-handed rotation amino group butanol to mixed rotation amino group butanol. The main device of high pressure racemism producing is G2Z-5 / 300-400 film compressor, ZJ-40 / 400 plunger type metering pump, high pressure reactor. The adopted medium is industrial liquid ammonia, content 99.6% industrial using hydrogen, cobalt touching coal as catalyst, and taking high pressure racemism reaction after hydrogenation activation. The pressure of high pressure racemism reaction is 20-22MPa, and reaction temperature is 170-190 degree centigrade. It would be changed into right-hand split material, and changed into right-hand amino group butanol after taking resin dissociation. The benefits of the invention are that changes three industrial wastes into products and lowers producing cost.

Description

technical field [0001] The invention relates to a method for producing d-2-aminobutanol-1, in particular to a method for producing d-2-aminobutanol-1 through L-aminobutanol. Background technique [0002] Hexaminobutanol is an important raw material for medicine and chemical industry. It is split into dextrorotary and levorotatory forms. Since the levorotatory form has no pharmacological activity, there is no report of practical application at present, and it has become "three wastes" in industry. [0003] The existing d-2-aminobutanol-1 manufacturing method is to split dl-2-aminobutanol-1 through a resolving agent to become a D-salt and a L-salt, and then free through ion exchange, and the eluent is distilled Thus, d-2-aminobutanol-1 and 1-2-aminobutanol-1 are obtained. Contents of the invention [0004] The technical problem to be solved in the present invention is to provide a production method of d-2-aminobutanol-1, aiming at solving the above-mentioned problems. [0...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/08C07C213/10C07C215/08
Inventor 冯桂春仲伟平
Owner 上海五洲同一药业有限公司