Use of Maoliefengdou extract for preparing anti-cancer medicine

A technology of Trichosanthes and extracts, which is applied in the field of medicine and can solve the problems such as the antitumor activity of butterbur

Inactive Publication Date: 2007-09-05
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to develop and utilize this plant, the present inventors have carried out systematic chemical composition and pharmacological research on this plant, and have reported four new butterbur lactone compounds and butterbur lactone compounds in Butterbur pilaris It is used for the treatment of diseases that may be related to histamine and / or leukotrienes (patent publication number: CN1844114), but so far, there has been no report that Butterbur pilaris and its extracts have anti-tumor activity

Method used

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  • Use of Maoliefengdou extract for preparing anti-cancer medicine

Examples

Experimental program
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Embodiment 1

[0033] Heat the dried rhizomes of Butterbur trichomes with 20-95% ethanol for heating and extraction, and the amount of solvent used for the first time is about 5-10 times of the crude drug amount, or extract the rhizomes of Butterbur trichomes by percolation with 20-95% ethanol, and the dosage of solvents is 5-15 times of the amount of crude drug, combined percolate, and concentrated under reduced pressure to a certain volume to obtain a concentrated solution, the centrifuged supernatant or filtrate of the concentrated solution is adsorbed by a macroporous resin, (the macroporous resin is a frame with styrene Polystyrene type porous adsorption resin of bridge material, such as: D101, D201, ZTC-1, AB-8, D4020, 860021, HP20, SP825 type macroporous resin, etc.), rinse with water-50% aqueous ethanol to remove Impurities; then elute with a water-containing lower alcohol with a concentration of 60-95%. The lower alcohol is C1-C5 alcohols such as methanol, ethanol, or propanol, and i...

Embodiment 2

[0035] Put 50 kg of dried rhizomes of Butterbur trichomes into a percolation tank, add 250 liters of 80% ethanol, soak for 12 hours, percolate, combine the percolation liquid, concentrate it under reduced pressure to 30 liters, centrifuge, and then pass through the macroporous adsorption resin SP825 (Beijing Lvbaicao Co.), rinsed with 300 liters of 40% ethanol to remove impurities; then eluted with 300 liters of 70% ethanol, collected the eluate, concentrated under reduced pressure and dried to obtain the extract of Butterbur pilaris of the present invention 0.25 kg.

[0036] The main active ingredients of the butterbur extract of the present invention are butterbur lactone D (bakkenolide-D), butterbur lactone B (bakkenolide-B), butterbur lactone-IVa (bakkenolide-IIIa) , butterbur lactone (bakkenolide-IIIa), the total content of the four is as high as more than 50%. Through in vitro tests, it can effectively prevent and treat tumors, especially liver cancer, lung cancer, cervi...

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Abstract

An application of the Japanese butterbur's extract (bakkenolide D, B, IVa and IIIa) in preparing the medicines for preventing and treating liver cancer, lung cancer, cervical cancer, intestinal cancer, kidney cancer, bread cancer, etc is disclosed.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular, to an extract of the rhizome of Butterbur pilaris and its preparation method and the use of the extract for preparing medicines for treating and preventing tumor diseases Background technique [0002] Petasites tricholobus Franch. belongs to the genus Petasites tricholobus Franch. Its rhizomes are used in the folk for detoxification and blood stasis, and for external application to treat bruises, fractures and snakebites. In order to develop and utilize this plant, the present inventors have carried out systematic chemical composition and pharmacological research on this plant, and have reported four new butterbur lactone compounds and butterbur lactone compounds in Butterbur pilaris It is used to treat diseases that may be related to histamine and / or leukotrienes (patent publication number: CN1844114), but so far, there has been no report that Butterbur pilaris and its ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P35/00
Inventor 郭美丽李润平张娜
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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