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Refined yinqiao detoxication dropping pill

A dripping pill and Yinqiao technology, applied in the field of medicine, can solve the problems of bioavailability of liver and intestine first-pass effect, increase in the cost of medication for patients, physical damage to staff, etc. The effect of low utilization and labor intensity

Inactive Publication Date: 2007-09-19
天津同仁堂集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Due to the preparation technology and other reasons, the oral preparations of traditional Chinese medicines have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the medicine and directly affect the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules, etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause damage to the health of the staff to a certain extent, and also It will have a certain impact on the environment; due to the complex production process and high production cost of conventional oral preparations, the cost of medication for patients will increase accordingly, so patients bear a greater economic burden during the medication process
[0012] From the analysis of the above aspects, there are certain limitations in conventional oral preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0084] The specific embodiment A specific example of realizing the present invention is as follows:

[0085] Take the raw materials according to the following weight ratio:

[0086] Acetaminophen 36g Platycodon 60g Forsythia 100g Tempeh 50g Bamboo leaves 40g Licorice 50g Honeysuckle 100g Burdock 60g Ears of Nepeta 40g Menthol 0.3g

[0087] Preparation:

[0088] (1) Ten flavors in the prescription, volatile oil extracted from the ears of Nepeta: acetaminophen and menthol are crushed into fine powder; the remaining Qiwei is extracted twice with water, the first time is 2 hours, the second time is 1 hour, and the water temperature for each extraction is 98 -102°C, filter the extract, combine the filtrates, concentrate the filtrate to a relative density of 1.17, add ethanol, let it stand for precipitation, take the supernatant, recover the ethanol, concentrate it into a thick paste, dry it, and pulverize it into a dry paste powder ( 100 mesh fine powder); spare.

[0089] (2) Ta...

example 1

[0092] Example 1 Selecting different substrates for the experiment of formulating

[0093] experimental design

[0094] In order to observe the influence of the pharmaceutical active ingredient and different substrates on the products involved in the formulation of the prescription, polyethylene glycol 2000 (molecular weight is 2000), polyethylene glycol 4000 (molecular weight is 4000), polyethylene glycol 6000 (molecular weight) respectively 6000), polyethylene glycol 8000 (molecular weight is 8000) and other substrates are uniformly mixed with the active ingredients of the drug in a ratio of 1:2, and the others are all in accordance with the conditions given in the [specific embodiment], that is, the auxiliary material polyethylene glycol Heating to melt, adding the active ingredients of the drug nepeta panicle oil, dry ointment powder, acetaminophen, and menthol fine powder, and mixing evenly to obtain a drug solution to be dripped. Adjust the temperature control device of...

example 2

[0096] Example 2 Experiments of different ratios of pharmaceutical active ingredients and substrates

[0097] experimental design

[0098] In order to observe the influence of the different proportioning ratios of the active ingredients of the drug and the substrate on the products involved in the present invention, polyethylene glycol 4000 (molecular weight is 4000) is selected as the substrate, and the drug is mixed with the ratio of (1:1)-(1:8) respectively. The active ingredient is uniformly mixed with the selected matrix, and the other conditions are given in [Detailed Embodiment], that is, the auxiliary material polyethylene glycol is heated to melt, and the active ingredient Nepeta ear oil, dry paste powder and acetaminophen are added. , Menthol fine powder, mix uniformly, obtain the medicinal liquid to be dripped. Adjust the temperature control device of the dropping pill machine so that the temperature of the dropping head of the dropping pill machine is heated and k...

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PUM

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Abstract

This invention relate to a refined chinese medicine Yinqiao Jiedu pills and preparation for cold therapy, characterized in that Dry Ointment Powder of the water extracts of Platcodon Grandiflorum, forsythia fruit, prepared soybean, Glycyrrhiza, Lophatherum gracile Brongn, honeysuckle, arctium fruit, oil of schizonepeta, Menthol, p-acetaminophenol as Active Constituents are made into pills. The objection of the invention is that it overcomes the deficiency of the present Technology, it discloses remarkable characteristics such as high bioavailability, release drugs quickly, significant curative effect, high drugs content, easy administration, lower price, Non-pollution in production. Said drugs have unique formula with the functions of expelling wind, inducing diaphoresis, clearing away heat. Pharmacodynamic study has verified that the performance of pills is superior to conventional oral preparation of refined Chinese medicine Yinqiao Jiedu tablets and it is worth using widely.

Description

technical field [0001] The invention relates to a refined Yinqiao Jiedu dripping pill for treating colds and a preparation thereof, belonging to the field of medicine. Background technique [0002] According to the ministerial drug standard WS 3 - Refined Yinqiao Jiedu Tablets prepared by the preparation method given in B-0660-91, is a kind of oral tablet that has the functions of clearing away heat and dispelling wind, relieving exterior and reducing fever, and is used for the treatment of influenza; Exactly, it is the drug of choice for clinical and family treatment of the above diseases. [0003] The following is the drug standard WS 3 -The formulation process and brief description given in B-0660-91: [0004] prescription: [0005] Paracetamol (acetaminophen) 72g Bellflower 120g Forsythia 200g [0006] Light tempeh 100g Licorice 100g Light bamboo leaves 80g Honeysuckle 200g [0007] Burdock fruit 120g Nepeta ear 80g Menthol 0.6g [0008] Preparation method: [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/20A61P31/00A61P29/00A61P11/00A61K31/045A61K31/167
Inventor 邵世宏
Owner 天津同仁堂集团股份有限公司
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