Method for preparing injection preparation of freeze drying powder of Xuesaitong

A technology of freeze-dried powder injection and Xuesaitong, which is applied in freeze-dried delivery, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of easy pollution and inconvenience in use, and achieves improved solubility, convenient and safe use. , the effect of improving solubility

Active Publication Date: 2007-10-10
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to provide a preparation method of Xuesaitong freeze-dried powder preparation for injection, which solves the problems that the existing Xuesaitong for injection needs to be dissolved with a special solvent before application, is inconvenient to use, and is easy to pollute, and is suitable for use in Those who are allergic to ethanol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Panax notoginseng extraction process

[0025] Take notoginseng, crush it, add 2 times the amount of 90% ethanol to soak for 12 hours, heat and reflux for extraction for 2 hours, and filter; add 1.5 times the amount of 90% ethanol for reflux extraction for 1.5 hours, filter, extract once more in the same way, and combine three times Recover ethanol from the filtrate, add purified water to dilute to 0.25g (crude drug) / ml, let it stand for 12 hours and then filter, and the filtrate is adsorbed by a D-101 macroporous adsorption resin column at a flow rate of 1.3±0.1BV / h, and the amount is 1 times that of the resin Rinse the resin column with purified water, then soak the resin with 70% ethanol of 1 times the amount of the resin for 30 minutes, elute with 70% ethanol of 4 times the amount of the resin at a flow rate of 1.0BV / h, and then use 1 times the amount of resin to elute Rinse the resin column with purified water. Collect eluate and flushing liquid, pass through D9...

Embodiment 2

[0030] 1. Panax notoginseng extraction process

[0031] Take notoginseng, crush it, add 1 times the amount of 95% ethanol to soak for 36 hours, heat and reflux for extraction for 3 hours, and filter; add 3 times the amount of 80% ethanol for reflux extraction for 1 hour, filter, combine the two filtrates to recover ethanol, add Dilute with purified water to 0.20g (crude drug) / ml, filter after standing for 48 hours, and the filtrate is adsorbed by the D-101 macroporous adsorption resin column at a flow rate of 1.2BV / h, and the resin column is washed with purified water 3 times the amount of the resin, Then soak the resin with 2 times the amount of 80% ethanol of the resin for 40 minutes, elute with 60% ethanol of 6 times the amount of the resin at a flow rate of 1.2BV / h, and then rinse the resin column with purified water of 2 times the amount of the resin. Collect eluate and flushing liquid, pass through D900 decolorizing resin at a flow rate of 6.2BV / h, then add 90% ethanol 3...

Embodiment 3

[0036] 1. Panax notoginseng extraction process

[0037] Take notoginseng, crush it, add 4 times the amount of 70% ethanol to soak for 48 hours, heat and reflux for extraction for 2.5 hours, filter; add 3 times the amount of 85% ethanol for reflux extraction for 2 hours, filter, extract once more in the same way, and combine three times Recover ethanol from the filtrate, add purified water to dilute to 0.40g (crude drug) / ml, and filter after standing for 24 hours. The filtrate is adsorbed by a D-101 macroporous adsorption resin column at a flow rate of 1.4BV / h, and purified with 2 times the amount of resin Rinse the resin column with water, then soak the resin with 60% ethanol 3 times the amount of the resin for 60 minutes, elute with 80% ethanol 5 times the amount of the resin at a flow rate of 1.0BV / h, and then use purified water 3 times the amount of the resin Rinse the resin column. Collect eluent and flushing liquid, pass through D900 decolorizing resin at a flow rate of ...

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PUM

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Abstract

A freeze-dried powder injection 'Xuesaitong' for treating thrombus is prepared from notoginseng through reflux extracting in alcohol, adsorbing by macroreticular resin, filtering to obtain liquid extract, adding precipient, and freeze-drying.

Description

technical field [0001] The invention relates to a preparation method of Xuesaitong freeze-dried powder preparation for injection, which belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Panax notoginseng, also known as Tianqi, ginseng notoginseng, jinbuhuan, and mountain lacquer, is a plant of the genus Panax notoginseng (Burk) F.H.Chen. in the Araliaceae family; it is a unique medicinal material species in my country. Li Shizhen said: "It was born in the deep mountains of Fantong, Nandan Zhuzhou, Guangxi. The roots are picked up and dried up, yellow and black. The solid matter is slightly white and white; the elder is like old dried rehmannia glutinosa, with knots. The taste is slightly sweet and bitter. , quite like the taste of ginseng". "Compendium of Materia Medica Supplements" said: "Ginseng is the first in nourishing qi, Sanqi is the first in nourishing blood, and is the most precious of traditional Chinese medicine." [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/19A61P9/10A61K125/00
Inventor 方同华周雪峰项彦华
Owner HEILONGJIANG ZBD PHARMA
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