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Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method, preparations and its application

A technology of traditional Chinese medicine preparations and compositions, which is applied in the field of preparation of drugs for the treatment of coronary heart disease, can solve the problems of unrepresentative, high cost, and large energy consumption of equipment, and achieve good anti-myocardial ischemia, increase coronary flow, The effect of simple preparation method

Inactive Publication Date: 2007-10-24
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of total alkaloids was not involved in the study, and the simple selection of tetrahydropalmatine monomer as the investigation index is not representative.
At the same time, the supercritical extraction method is not widely used, its cost is high, the equipment consumes a lot of energy, the total alkaloid content of the prepared Corydalis Corydalis is unknown, and there are still many impurities, so it cannot be used as a medicine for human body

Method used

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  • Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method, preparations and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 The preferred preparation method of total alkaloids of Corydalis and its application in the preparation of drugs for the treatment of coronary heart disease

[0043] Take the Corydalis Corydalis medicinal material, crush it into a coarse powder passing through a 20-mesh sieve, soak it with 0.5% hydrochloric acid solution 16 times the weight of the medicinal material for 24 hours, and then percolate. Elution, then elution with 10% ethanol 3 times the volume of the resin to remove impurities, and finally elution with 50% ethanol 12 times the volume of the resin, collect the eluate, concentrate under reduced pressure at 60 ° C to a relative density of 1.10 to 1.20 The extract is spray-dried and pulverized to obtain the effective fraction of the total alkaloids of Corydalis Corydalis. The content of total alkaloids is 85%.

[0044] The following pharmacological test is carried out for the effective parts of the obtained total alkaloids of Corydalis Corydalis, tha...

Embodiment 2

[0055] Example 2 The preferred preparation method of total alkaloids of Corydalis Corydalis

[0056] Take the Corydalis Corydalis medicinal material, crush it into a coarse powder passing through a 20-mesh sieve, soak it with 0.5% sulfuric acid solution 16 times the weight of the medicinal material for 24 hours, and then percolate. The percolation liquid is absorbed by a D101 macroporous adsorption resin column. Eluted with water, then eluted with 20% ethanol 4 times the volume of the resin to remove impurities, and finally eluted with 70% ethanol 10 times the volume of the resin, collected the eluate, concentrated under reduced pressure at 60°C to a relative density of 1.10-1.20 The extract is vacuum-dried and pulverized to obtain the effective fraction of the total alkaloids of Corydalis Corydalis. The content of total alkaloids is 80%.

Embodiment 3

[0057] Example 3 The preferred preparation method of Corydalis total alkaloids

[0058] Take the Corydalis Corydalis medicinal material, crush it into a coarse powder passing through a 20 mesh sieve, soak it with 1% hydrochloric acid solution of 14 times the weight of the medicinal material for 12 hours, and then percolate. The percolation liquid is absorbed by a Dm301 macroporous adsorption resin column. Eluted with water, then eluted with 40% ethanol 2 times the volume of the resin to remove impurities, and finally eluted with 90% ethanol 6 times the volume of the resin, collected the eluate, concentrated under reduced pressure at 60°C to a relative density of 1.10-1.20 The extract is freeze-dried and pulverized to obtain the effective fraction of the total alkaloids of Corydalis Corydalis. The content of total alkaloids is 62%.

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Abstract

The invention relates to a traditional Chinese pharmaceutical composition for treating coronary disease and process for preparation, wherein the composition is the significant portion of corydalis ambigua total alkaloid extracted from the medicinal material of corydalis ambigua, the alkaloid content is higher than 60%. The invention also provides the medicinal preparation of the Chinese medicinal composition and the use in preparing medicament for treating coronary disease.

Description

technical field [0001] The invention belongs to the technical field of research and development of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition containing effective parts of total alkaloids of Corydalis Corydalis, a preparation method thereof and an application in preparation of medicines for treating coronary heart disease. Background technique [0002] Corydalis yanhusuo, also known as Yuanhu, is recorded in the "Pharmacopoeia of the People's Republic of China" (2005 edition), and is the dry tuber of Corydalis yanhusuo W.T.Wang, a plant of the family Poppyaceae. Excavate when the stems and leaves wither in early summer, remove fibrous roots, wash, boil in boiling water until there is no white heart, take out and dry in the sun. Spicy, bitter, warm in nature. Return liver, spleen channel. Promote blood circulation, benefit Qi, relieve pain. It is used for chest pain, epigastric pain, amenorrhea dysmenorrhea, postp...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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