Milkwort extract, its preparation method and application

A technology of extract and polygala, applied in the field of polygala extract, can solve the problems of low safety and no effective parts of polygala to prepare safe, effective, stable and controllable products, etc., and achieves high safety, clear and controllable efficacy. strong effect

Inactive Publication Date: 2007-10-31
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low clinical safety
At present, there is no report on the preparation of safe,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of Polygala extract of the present invention

[0026] Take the coarse powder of Polygala medicinal material, decoct and extract 3 times with 8 times the amount of water, each time for 2 hours, filter, combine the extracts, concentrate to a solution with a relative density of 1.03-1.05 (50°C thermal measurement), let cool, add water Its concentration is adjusted to be 0.25g / L (containing crude drug polygala amount is 0.25g in every 1L medicinal liquid), leave standstill overnight, filter, pass through the well-processed D101 type macroporous adsorption resin column (the ratio of resin amount and crude drug amount is 3:10), eluted with water 3BV, discarded the water, then eluted with 30% ethanol 3BV, discarded the 30% ethanol eluate, followed by elution with 70% ethanol 3BV, collected the eluate, and decompressed Recover the ethanol, continue to concentrate to a clear paste with a relative density of 1.15 (by heat measurement at 50°C), and spray dry ...

Embodiment 2

[0027] Embodiment 2 Preparation of pharmaceutical capsules of the present invention

[0028] a. The amount of raw materials and auxiliary materials: 225 g of total saponins of polygala (prepared according to the method of Example 1), 25 g of starch, made into 1000 grains;

[0029] b. The yield of polygala extract is 3%. The extract is mixed with auxiliary materials, sieved through a 60-mesh sieve, and filled into No. 1 capsules to obtain 1000 capsules. The specification is 0.25g per capsule, 2 capsules per serving.

Embodiment 3

[0030] Embodiment 3 Preparation of pharmaceutical tablet of the present invention

[0031] a, the amount of raw materials and auxiliary materials: 225g of total saponins of polygala (prepared according to the method of Example 1), 25g of microcrystalline cellulose, made into 1000 tablets;

[0032] b. The yield of Polygala extract is 3%. The extract is mixed with auxiliary materials, sieved through a 40-mesh sieve, and directly compressed into tablets to obtain 1000 tablets, the specification is 0.25g per tablet, and 2 tablets are taken each time. Or crush the extract into fine powder, mix with auxiliary materials, moisten with ethanol and granulate, make granules and press into tablets to obtain.

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PUM

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Abstract

The invention provides an polygala root extract which comprises polygala root saponin with a weight percent of no less than 55. 0% (calculated by oleanolic acid C30H4803, polygalain acid C20H4406 no less than 21%. The invention also provides the process for preparing the medicinal composition and related dose forms.

Description

technical field [0001] The invention relates to an extract of polygala, in particular, an extract prepared from the traditional Chinese medicine polygala, belonging to the field of medicine. Background technique [0002] Insomnia is the most common sleep disorder, also known as sleep initiation and maintenance disorders. According to Rosekind (1992), insomnia refers to the disturbance of the normal sleep of the patient, which has obvious adverse effects on the patient's daytime activities (fatigue, decreased concentration, drowsiness, etc.), and at the same time, there are abnormalities in objective tests (such as polysomnography) syndrome. Traditional Chinese medicine refers to insomnia as "insomnia", "insomnia", "not lying down", etc. It is characterized by difficulty in falling asleep, easy to wake up after sleeping, and no longer falling asleep after waking up, that is, shortened sleep time. [0003] The medicine for the treatment of insomnia at present has Chinese med...

Claims

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Application Information

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IPC IPC(8): A61K36/69A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P25/20A61K125/00
Inventor 万德光刘友平彭成
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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