Dehydroandrographolide succinate semialdehyde compound, its production and medicine
A technology for dehydrating Andrographis paniculata paniculata and succinic acid, which can be used in drug combinations, antipyretics, organic chemistry, etc. It can solve the problems of compound singleness and limitations, achieve the effects of reducing toxicity, improving drug efficacy, and overcoming use limitations
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Embodiment 1
[0014] Add 26.6 g (0.05 mol) of dehydrated andrographolide succinic acid half ester, 0.05 mol of corresponding amino acid and 300 ml of distilled water successively in the reaction flask, stir and react at 60°C to a clear liquid, evaporate the solvent to dryness under reduced pressure, and in the residue Add 300ml of acetone, grind to obtain an off-white precipitate, filter, wash the solid with a small amount of acetone twice, and dry under reduced pressure at 80°C to obtain the corresponding product. The yield and content results of the product compounds formed by different amino acids are shown in Table 1.
[0015] serial number
Embodiment 2
[0017] Take 26.6 g (0.05 mol) of dehydrated andrographolide succinic acid half ester and dissolve it in 100 ml of methanol; take another 0.05 mol of the corresponding amino acid and dissolve it in 300 ml of distilled water. Add the methanol solution of andrographolide succinic acid half ester dropwise to the amino acid aqueous solution, and stir the reaction at 40°C to a clear liquid. The solvent was evaporated under reduced pressure, 300ml of acetone was added to the residue, and the off-white precipitate was ground, filtered, and the solid was washed twice with a small amount of acetone, and dried under reduced pressure at 80°C to obtain the corresponding product. The yield and content results of the product compounds formed by different amino acids are shown in Table 2.
[0018] serial number
Embodiment 3
[0020] Add 26.6 g of dehydrated andrographolide succinate half ester, (0.05 mol), 0.05 mol of the corresponding amino acid and 300 ml of distilled water in sequence in the reaction flask, and stir the reaction at 60° C. to a clear liquid. After the solvent was evaporated to dryness under reduced pressure, it was freeze-dried to obtain the corresponding product. The yield and content results of the product compounds formed by different amino acids are shown in Table 3.
[0021] serial number
PUM
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