Device for inducing tumor cell apoptosis by high-voltage nanosecond pulse

A technology of tumor cell apoptosis and nanosecond pulse, which is applied in the field of high-voltage nanosecond pulse treatment of tumor devices

Active Publication Date: 2007-12-12
REMEDICINE CO LTD
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  • Description
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  • Application Information

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Problems solved by technology

Although this method fundamentally avoids the toxic and side effects of chemotherapy dru...

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  • Device for inducing tumor cell apoptosis by high-voltage nanosecond pulse
  • Device for inducing tumor cell apoptosis by high-voltage nanosecond pulse
  • Device for inducing tumor cell apoptosis by high-voltage nanosecond pulse

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Embodiment Construction

[0027] The present invention will be further described below in combination with specific embodiments.

[0028] As shown in Figures 1-6, a device for inducing apoptosis of tumor cells by high-voltage nanosecond pulses mainly includes a high-voltage direct current module 1, a pulse forming system 2, a pulse measurement system 3, a computer system 4, and a power supply system 5. The power supply system 5 is composed of a power supply, a power filter, an isolation transformer and a plug-in board. The power supply is 220V / 50Hz commercial power. It is connected to the input terminal of the isolation transformer to filter and isolate the input power; the output terminal of the isolation transformer is connected to the power strip through the power cord, and the output terminal of the power strip is respectively connected to the high-voltage DC module with the power cord 1. The preheating transformer B1 of the pulse forming system 2 and one end of the foot switch, the oscilloscope of...

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Abstract

A device for inducing apoptosis of tumor cell with high voltage nanosecond pulse belongs to technology field of electric impulse for treatment of tumor. The inventive device mainly comprises high voltage direct current module, pulse formation system, pulse measurement system, computer system, and power system. Amplitude value of high voltage nanosecond pulse is continuously regulated or preset between 0-9.9kV, repetition frequency is continuously regulated or preset between 2-100Hz, width is continuously regulated or preset between 200ns-1 mu s by separating to 7 grades, and numbers is regulated or preset according to treatment requirement. As the inventive device can induce apoptosis of tumor cell, is an unalloyed physical method, has no requirement of medicament assistance, thus can completely avoid toxic and adverse side effect of chemotherapeutics during treatment and adverse reaction such as inflammation, pain, ulcer and stammer, therefore the inventive device can be widely used in oncotherapy and treatment of removing polypus and redundant grease and vulvopathy.

Description

technical field [0001] The invention belongs to the technical field of electric pulse therapy for tumors, in particular to a device for treating tumors with high-voltage nanosecond pulses. Background technique [0002] In the 1970s, it was found that under the action of a pulsed electric field with a field strength of 1kV / cm and a pulse width of 100μs, the lipid bilayer of the cell membrane was temporarily rearranged to form some hydrophilic channels called micropores. , After the pulse electric field is withdrawn, the micropore will close by itself without any impact on the cells. This phenomenon is called reversible electroporation (REP). In recent years, studies have found that increasing the pulsed electric field dose to induce reversible electroporation (increasing the pulse amplitude or pulse width or the number of pulses), the cell membrane will not heal after perforation, the integrity will be damaged, and the cells will coagulate and die. This phenomenon is called ...

Claims

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Application Information

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IPC IPC(8): A61N1/10A61N1/34A61N1/02A61B18/00
Inventor 姚陈果米彦李成祥杜林莫登斌廖瑞金李剑孙才新
Owner REMEDICINE CO LTD
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