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Saponins antineoplastic compound in Bohadschia argus Jaeger

A technology of anti-tumor drugs and compounds, applied in the field of medicine

Inactive Publication Date: 2007-12-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The chemical structure and antitumor activity of the contained saponins have not been reported so far

Method used

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  • Saponins antineoplastic compound in Bohadschia argus Jaeger
  • Saponins antineoplastic compound in Bohadschia argus Jaeger

Examples

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Effect test

Embodiment 1

[0037] Embodiment 1: the separation and preparation of Arguside B and C

[0038] Select 2,200 grams of dried ginseng grown in the South China Sea of ​​Hainan Province, China, and soak and extract with 5 times the weight of 85% ethanol sequentially after crushing for 3 times, each soaking for 7 days. The ethanol extracts were combined, and the ethanol was recovered under reduced pressure to obtain a liquid extract. Dissolve the liquid extract in 3 times the amount of water, filter, pass the filtrate through a D101 macroporous resin column, and extract with petroleum ether and water-saturated n-butanol for 4 times, 500ml each time. The n-butanol extracts were combined, and the solvent was recovered under reduced pressure to dryness to obtain 28 grams of total saponins. The total saponins were subjected to silica gel column (200-300 mesh) chromatography, eluted with about 1500 ml of a mixed solvent of chloroform: methanol: water = 8 ~ 6.5: 2 ~ 3.5: 1, and the fraction containing...

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Abstract

The invention relates to medical technique, which in detail relates to a saponin antineoplastic compound Arguside B or Arguside C. The R1 in structure general formula represents OH or H, R2 represents CH3 or CH2OH, when R1 is OH and R2 is CH3, the compound is Arguside B; when R1 is H and R2 is CH2OH, the compound is Arguside C. The chemical structure and spatial configuration of said two compounds are determined through various modern spectral analysises, especially through analysis with multiple advanced nuclear magnetic resonance spectroscopy. It is tested that said two compounds are apparently inhibitive to seven cancers such as A- 549 lung cancer and MCF- 7 breast cancer. It can be used to prepare antineoplastic medicine. The invention provides leading compound for new antineoplastic medicine development, and is valuable for ocean biological resource utilization in China.

Description

technical field [0001] The invention relates to the technical field of medicine, and is novel antitumor compound Arguside B and C of saponins isolated from the sea animal Rhizoma chinensis. Background technique [0002] Bohadschia argus Jaeger (Bohadschia argus Jaeger) is a sea cucumber species that grows in large numbers in the South my country Sea, belonging to the genus Bohadschia argus Jaeger. The body length is generally 40-50cm, the width is about 10cm, and the body is cylindrical. There are many snake-like markings on the back, arranged in irregular longitudinal rows. Snake order white ginseng is a large edible sea cucumber. The chemical structure and antitumor activity of the contained saponins have not been reported so far. Contents of the invention [0003] The present invention provides a new saponin compound extracted and separated from Nishen chinensis grown in the South China Sea of ​​Hainan Province, China, named Arguside B and Arguside C respectively, an...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61K35/56A61K31/7048A61P35/00A61K35/616
Inventor 易杨华刘宝姝李玲
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY