Process for preparation of 3-(2-hydroxy-5-methylphenyl)-n,n-diisopropyl-3phenylpropylamine

A technology of methylphenyl and diisopropyl, applied in the field of organic chemistry, can solve problems such as short time and low price
CN101087751BInactive Publication Date: 2011-11-02LEK PHARMA D D
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LEK PHARMA D D
Publication Date
2011-11-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

A new process for preparation of 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine from 3,4-dihydro-6-methyl-4-phenyl-2-benzopyran-2-one is characterized by intermediates such as 3-(2-hydroxy-5-methyl phenyl)-3- phenylpropanol and its sulphonated derivatives and amination in presence of sodium iodide.
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Description

technical field

[0001] The invention belongs to the field of organic chemistry and relates to a novel and effective synthetic method for preparing 3-(2-hydroxyl-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine, which is characterized in The key intermediate lies in the readily available 3-(2-hydroxy-5-methylphenyl)-3-phenylpropanol. Background technique

[0002] Several synthetic methods for the preparation of 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine have been disclosed. The prior art describes the preparation of racemic and enantiomerically pure products obtained either by resolution of the enantiomers in a final step or by chiral synthesis.

[0003] EP325571 discloses a multi-step process for the preparation of 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine from 4-(-methoxy -5-methylphenyl)-6-methyl-3,4-chromanone as the first intermediate. Opening of the lactone ring in an alkaline medium with simultaneous esterification of ...

Claims

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