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Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same

A particle and phosphazene technology, applied in the field of treatment and/or diagnostic use of loadable particles containing polyphosphazene and its preparation and application, can solve the problem of difficulty in suspension

Active Publication Date: 2007-12-19
VARIAN MEDICAL SYSTEMS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] And when clear, transparent polymeric acrylate hydrogel beads are used in aqueous suspension, it is also difficult to visualize the microparticles in solution to determine the degree of suspension

Method used

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  • Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
  • Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
  • Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same

Examples

Experimental program
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Effect test

Embodiment 1

[0080] Microspheres with a diameter of approximately 500 to 600 μm were prepared. First, prepare the polymer solution, including the molecular weight 3 × 10 6 The g / mol of PTFEP polymer was dissolved in the polymer solvent ethyl acetate to obtain a 2% (wt / v) polymer solution. 4 ml of this polymer solution was manually added dropwise into liquid nitrogen using a 5 ml syringe. The dispersion was dispersed on a frozen layer of 150 ml pentane (see Figure 2). A 3-day cryogenic extraction was carried out. Subsequently, the polymer particles were recovered from the reaction tube and air-dried at 21 °C.

Embodiment 2

[0081] Microspheres with a diameter of approximately 350 to 450 μm were prepared. First, prepare the polymer solution, including the molecular weight 3 × 10 6 The g / mol of PTFEP polymer was dissolved in ethyl acetate to obtain a 1% (wt / v) polymer solution. 4 ml of this polymer solution was manually added dropwise into liquid nitrogen using a 5 ml syringe. The dispersion was dispersed on a frozen layer of 150 ml pentane (see Figure 2). A 3-day cryogenic extraction was carried out. Subsequently, the polymer particles were recovered from the reaction tube and air-dried at 21 °C.

Embodiment 3

[0082]Microspheres with a diameter of approximately 500 to 600 μm were prepared. First, prepare the polymer solution, including the molecular weight 12 × 10 6 The g / mol of PTFEP polymer was dissolved in methyl isobutyl ketone to obtain a 2% (wt / v) polymer solution. 4 ml of this polymer solution was manually added dropwise into liquid nitrogen using a 5 ml syringe. The dispersion was dispersed on a frozen layer of 150 ml of a 1:9 (v / v) mixture of ethanol / pentane (see Figure 2). A 3-day cryogenic extraction was carried out. Subsequently, the polymer particles were recovered from the reaction tube and dried under low pressure at 21°C.

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Abstract

Particles are provided for use in therapeutic and / or diagnostic procedures. The granules include poly[bis(trifluoroethoxy)phosphazene] and / or derivatives thereof, which may be present throughout the granule or in the outer coating of the granule. The particle may also include a core comprising a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided as a coating on the core of the granules or absorbed into the core of the granules. The particles can be used to minimize blood flow to mammalian tissues, including occluding at least a portion of a blood vessel in a mammal, or to deliver an active agent to a localized area in a mammalian body by contacting at least one particle with the localized area. Further, the particles are useful in oral sustained release formulations containing active agents, as tracer particles for injection into the bloodstream of mammals, or for use in enhanced ultrasound imaging. The particles may include density increasing agents to achieve useful levels of flotation in suspension.

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C.ξ119(e) to provisional patent applications 60 / 684,307, filed May 24, 2005, and 60 / 621,729, filed October 25, 2004, the entire contents of which are incorporated herein by reference . Background technique [0003] Smaller particles, including microspheres and nanospheres, have many clinical applications in diagnostic and therapeutic procedures. Most prior art particles used in medical applications are characterized by a number of disadvantages, including irritation of tissues with which they come in contact and eliciting deleterious immune responses. [0004] Furthermore, many of the substances used to prepare prior art particles can degrade relatively quickly in mammalian bodies, thus detracting from their use in processes where some intact particles must exist for extended periods of time. Furthermore, the degradation of prior art substances can release toxic or irritati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/50A61K9/51
Inventor P・哈德尔O・弗里茨U・弗里茨
Owner VARIAN MEDICAL SYSTEMS
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