Method for preparing standard of nisoldipine

A technology for nisoldipine and standard products, which is applied in the field of preparation of nisoldipine compound standard products, can solve the problems such as the inability to obtain high-purity nisoldipine standard products, and achieves the effects of simple operation, high product purity and stable process.
CN101092390AInactive Publication Date: 2007-12-26SHANDONG XINHUA PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG XINHUA PHARMA CO LTD
Publication Date
2007-12-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides a novel method for preparing standard nisoldipine product. The method comprises: dissolving crude nisoldipine into C3-6 lower ketone and recrystallizing, or dissolving crude nisoldipine into C3-6 lower ketone, mixing with C3-6 lower alcohol, and recrystallizing. The method has such advantages as stable process, easy operation, high product purity (above 99.5%), and no pollution.
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Description

technical field

[0001] The invention relates to a preparation method of a nisoldipine compound standard product. Background technique

[0002] Nisodipine of the following structural formula is a calcium antagonist. It can selectively inhibit vascular smooth muscle, reduce myocardial oxygen consumption, and blood pressure will decrease significantly with the increase of dose. For antihypertensive, antianginal and atypical angina.

[0003]

[0004] Several processes for the preparation of nisoldipine have been described in the literature so far. But all can not obtain the high-purity nisoldipine standard substance. Contents of the invention

[0005] The technical problem to be solved by the present invention is to provide a new refining method for preparing nisoldipine standard product, which has stable process, simple operation, high product purity and no pollution.

[0006] The preparation method of nisoldipine standard substance of the present invention is characte...

Claims

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