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Bone peptide injection preparation technology

A technology for preparation of injections and osteopeptides, which is applied in the field of medicine, can solve the problems of allergic reactions, the impossibility of intravenous injection of injections, and the possibility of allergic reactions, so as to reduce the effect of toxic reactions

Inactive Publication Date: 2008-01-16
石海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its main disadvantages are: ① Adding phenol to inhibit bacteria in the process makes intravenous injection of injection impossible
② During the process, a small amount of proteins and peptides with a molecular weight of 10,000 remain, which can easily lead to allergic reactions. When administered intravenously, almost all allergic reactions occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The process of the present invention is:

[0017] a. Extraction, degreasing, and concentration: Take healthy and fresh pig limb bones, wash, smash, weigh, add water to the raw materials, heat press, filter with gauze, add water to the bone residue, heat press, filter, and combine twice The filtrate is immediately placed in a jacketed pot, passed through cooling water, cooled to room temperature, placed in a cold storage, and transferred to a cold room after cooling to 0-5°C, skimmed off the upper layer of fat, and heated to melt the jelly. Liquid, concentrated or vacuum concentrated to obtain a concentrated solution;

[0018] b. Precipitation and concentration: take the concentrated solution and add ethanol, let it stand for precipitation, remove impurity proteins, obtain the supernatant, and then concentrate in vacuo;

[0019] c. Acidic precipitation and alkaline precipitation: add hydrochloric acid to the above liquid under stirring, adjust to pH value, and heat unde...

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PUM

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Abstract

Disclosed is a preparation process of ossotide injection (gutai), belonging to the medical technical field. To solve the defects of the existing ossotide injection (gunning), the novel ossotide injection (gutai) preparation process is produced by the change of the existing ossotide injection (gunning) process. In the invention, four bones of a pig is picked up, degreased, condensed, and then precipitated and condensed, and then after acid precipitation and alkaline precipitation, the heated liquid is cooled to be in the room temperature and then is placed in a refrigerator; the liquid is taken out from the refrigerator and acidic protein is removed from the liquid is filtrated and hyperfiltrated to become the ossotide stock solution which is mixed with water, filtrated, potted and sterilized, thus the ossotide injection (gutai) is prepared well. The invention removes sensitizer and toxicant, largely reduces toxic reaction for the ossotide injection (gutai), and makes medicine for intravenous injection possibly used.

Description

Technical field: [0001] The invention belongs to the technical field of medicine. Background technique: [0002] At present, the detailed preparation process of Guning Injection is recorded in "Biochemical Pharmacy" published by China Medical Publishing House. Guning Injection is an injection prepared from pig limb bones. The main component is polypeptide or protein peptide , Quantitative analysis of emission spectrum contains trace elements, mainly Ca, Mg, Al, Fe, other trace elements include Mn, Ba, Cu, Pb, Sn, Ti, Zr, etc., the content is about 1μg / ml. The contained ingredients are soluble in water and ethanol below 75%, and can be precipitated by 10 times the amount of acetone. The pH of the aqueous solution is 4 and 8.5 without precipitation. It is stable to heat and does not lose its pharmacological effect when heated for a long time. Its main disadvantages are: ①Adding phenol to inhibit bacteria in the process makes intravenous injection of injection impossible. ② D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61K38/17A61P19/08
Inventor 石海韩英
Owner 石海
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