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Suppository for treating colitis and method of preparing the same

A colitis and suppository technology, applied in suppository delivery, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory curative effect in the rectum, gastrointestinal irritation, liver damage, etc. , to achieve the effect of less toxic and side effects, good therapeutic effect and low price

Active Publication Date: 2008-02-27
黑龙江天宏药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Chronic colitis (ulcerativecolitis, uc) is a disease with a worldwide distribution, its incidence rate is 5-12 / 100,000 in the West, and the prevalence rate is 50-150 / 100,000; the overall incidence population in Asia is about 75.1 million , showing an upward trend in recent years, and the existing drugs for the treatment of colitis in China are all taken orally. Oral drugs can stimulate the gastrointestinal tract and damage the liver; the curative effect of oral drugs on the rectum is not ideal.
The suppository of imported medicine is more expensive, and because of the matrix used, the stability is poor, and it is easy to change color after a period of time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0037] Specific embodiment 1: get main drug mesalazine 500g, matrix polyoxyhydrogen (40) stearate 1000g, adjuvant include adhesive and lubricant, adhesive adopts povidone K 30 . Lubricants are magnesium stearate and talcum powder, and povidone K 30 70g, magnesium stearate and talcum powder 30g, technical process: the main drug mesalazine passes through a 100 mesh sieve, the matrix polyoxyhydrogen stearate (40) passes through a 22 mesh sieve, and the rest of the auxiliary materials pass through a 100 mesh sieve, for subsequent use; 25% Povidone K 30 The aqueous solution is used as a binder, and only the main drug is made into a soft material, granulated with a 22-mesh sieve to obtain wet granules; ventilated at 60°C, dried, and granulated with a 20-mesh granule to obtain drug granules; the drug granules and matrix granules are mixed according to the prescription ratio , mix evenly, add magnesium stearate and talcum powder, mix evenly; use the cold pressing method in the suppo...

specific Embodiment approach 2

[0038] Specific embodiment 2: get mesalazine 750g, polyoxyl (40) stearate 750g, povidone K 30 80g, magnesium stearate and talc powder 20g, the preparation method is the same as that of Embodiment 1, and each grain contains 750mg of mesalazine.

specific Embodiment approach 3

[0039] Specific embodiment 3: get mesalazine 1000g, polyoxyl (40) stearate 500g, povidone K 30 90g, magnesium stearate and talcum powder 10g, the preparation method is the same as the specific embodiment 1, and each grain contains mesalazine 1000mg.

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PUM

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Abstract

The invention discloses a suppository and making method to treat colitis, which comprises the following parts: 25-150wt% meisalaqin, 25-150wt% stearic polyhydrogenoxygen ester (40) and 6-14wt% findings. The making method comprises the following steps: sieving the meisalaqin through 80-100 order; passing stearic polyhydrogenoxygen ester through 16-24 order; making the findings pass 80-100 order sieve; using adhesive to pass the main agent material into 16-24 sieve to obtain wet particle; venting under 50-70 deg. c; drying; trimming particle at 16-20 order; blending the drug particle and base particle proportionally; adding lubricant; blending evenly to press; packing; obtaining the product.

Description

Technical field: [0001] The invention relates to a suppository for treating ulcerative colitis by rectal administration and a preparation method thereof. Background technique: [0002] Chronic colitis (ulcerativecolitis, uc) is a disease with worldwide distribution, its incidence rate is 5-12 / 100,000 in the West, and the prevalence rate is 50-150 / 100,000; the overall incidence population in Asia is about 75.1 million , On the rise in recent years, and the existing medicines for the treatment of colitis in China are all taken orally. Oral medicines can stimulate the gastrointestinal tract; The suppositories of imported medicines are more expensive, and because of the matrix used, they are less stable and tend to change color after a period of time. Invention content: [0003] The purpose of the present invention is to provide a drug that does not irritate the gastrointestinal tract, can avoid the damage of the drug to the liver and the first-pass effect of the drug on the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/606A61K9/02A61K47/34A61P1/00A61K47/14A61K47/32
Inventor 宁树一魏凯赫秋丹
Owner 黑龙江天宏药业股份有限公司