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Medicament of expectorant anti-asthma, preparing method and function thereof

A drug, anti-asthma technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of adverse reactions, high price, no recognized rapid control of acute asthma attacks and significant prevention of asthma recurrence. , to achieve a good expectorant effect

Inactive Publication Date: 2010-09-01
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of glucocorticoids is relatively definite, but it has local and systemic adverse reactions
Anti-leukotriene drugs have fewer adverse reactions but are more expensive
[0007] Although there are many drugs for treating phlegm, there is no recognized traditional Chinese medicine preparation that can quickly control the acute attack of asthma and significantly prevent the recurrence of asthma

Method used

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  • Medicament of expectorant anti-asthma, preparing method and function thereof
  • Medicament of expectorant anti-asthma, preparing method and function thereof
  • Medicament of expectorant anti-asthma, preparing method and function thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Take Desert Ga or Desert Ga seeds, pulverize them, pass through a 40-mesh sieve, add 10 times the amount of 80% ethanol to heat and reflux to extract twice for 2 hours each time, combine the filtrates, concentrate and evaporate to dryness to obtain Drug A.

Embodiment 2

[0073] 1. Put the drug A obtained in Example 1 on a silica gel column, the weight ratio of the weight of the silica gel to the dry crude extract is 4: 1 (Kg / Kg), use chloroform to elute, and the eluent is concentrated to obtain the extract;

[0074] 2. continue to go up the silica gel column with the extractum obtained in step 1 and adopt cyclohexane-acetone gradient elution, the condition of gradient elution adopts thin-layer chromatography (TLC) to control, and the condition of thin-layer separation is as follows: stationary phase It is a silica gel G plate, the developing agent is cyclohexane-acetone=2:1, and the developing agent is 1% aluminum chloride solution. Use cyclohexane to elute first, until spray 1% aluminum trichloride solution and then put UV 365 When there are green fluorescent spots on the bottom, use cyclohexane-acetone (10:1) solvent to elute, and use the same method and conditions of thin-layer chromatography to track and identify until after spraying 1% al...

Embodiment 3

[0076] 1. The drug A obtained in Example 1 is put on a silica gel column, the weight ratio of the weight of the silica gel to the dry crude extract is 4: 1 (Kg / Kg), and ethyl acetate is used for elution, and the eluent is concentrated to obtain the extract ;

[0077] 2. The medicinal extract obtained in step 1 continues to go up the silica gel column and adopts cyclohexane-acetone (6: 1) gradient elution, and the condition of gradient elution adopts thin-layer chromatography (TLC) to control, and the thin-layer separation The conditions are as follows: the stationary phase is silica gel G plate, and the developer is cyclohexane-acetone=2:1. When red spots appear after spraying 10% sulfuric acid ethanol solution, use cyclohexane-acetone (4:1) solvent instead Carry out elution, also adopt the aforementioned thin-layer chromatography method and condition to track and identify, until after spraying 10% sulfuric acid ethanol solution, when there are no other impurities except red s...

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PUM

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Abstract

The invention relates to an expectorant anti-asthmatic drug, a preparation method and purpose. Substantially, the artemisia halodendron Turcz is adopted for preparing the expectorant anti-asthmatic drug further by taking the method of alcohol refluxing extraction.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for eliminating phlegm and relieving asthma, its preparation method and application. Background technique [0002] Desert Ga, the original plant is Artemisia halodendron Turcz., a plant of the genus Artemisia in the family Asteraceae. It is pungent in taste and warm in nature. Indications of chronic bronchitis, asthma; rheumatoid arthritis. Chinese Pharmacopoeia (2005 edition) has not yet recorded it. [0003] Bronchial asthma is a chronic airway inflammatory disease involving various cells and cell components. This chronic inflammation leads to an increase in airway hyperresponsiveness, and the main clinical symptoms are recurrent wheezing, shortness of breath, chest tightness, or coughing. [0004] In the past, the treatment of asthma was mainly based on the application of bronchodilators. With the deepening of asthma research, it was discovered that as...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/282A61P11/06A61P11/10A61K127/00A61K135/00
Inventor 乔延江张媛媛史新元张燕玲艾路
Owner BEIJING UNIV OF CHINESE MEDICINE
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