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Chinese medicine extract combination and medicine use thereof

A technology of extracts and compositions, applied in the field of extracts and compositions of traditional Chinese medicines, to avoid drug withdrawal rebound and improve microcirculation

Active Publication Date: 2011-11-16
湖南药圣堂中药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are many medicines for treating diabetes (DM) on the market. Chemical medicines lower blood sugar quickly, but there are problems such as "rebound after drug withdrawal" and severe side effects; The curative effect of traditional Chinese medicine is generally uncertain, especially the single herb preparation
However, there is currently no specific drug for the treatment of diabetic retinopathy (DR) on the market.

Method used

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  • Chinese medicine extract combination and medicine use thereof
  • Chinese medicine extract combination and medicine use thereof
  • Chinese medicine extract combination and medicine use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The present embodiment is the pharmaceutical composition (hard capsule) that is made by the Chinese medicine extract of following proportioning by weight:

[0066] Three needles total alkaloid extract 6 parts, cucumber root extract 5 parts, loropetalum leaf extract 9 parts.

[0067] in:

[0068] The three needles total alkaloid extract is the substance extracted from the three needles by the following method:

[0069] Take three needles of medicinal materials, add 12 times the amount of 0.5% sulfuric acid aqueous solution to soak for 24 hours, then percolate at a speed of 3ml per minute, collect the percolation liquid, add lime milk to the percolation liquid to adjust the pH value to 5, filter, add the filtrate Adjust the pH value to 1 with hydrochloric acid, add sodium chloride to make the salt content 10%, let it stand for 48 hours, filter to obtain a precipitate, wash the precipitate with water until the pH value reaches 5, dry, and pulverize to obtain the total al...

Embodiment 2

[0077] The present embodiment is the pharmaceutical composition (hard capsule) that is made by the Chinese medicine extract of following proportioning by weight:

[0078] Three needles total alkaloid extract 5 parts, cucumber root extract 5 parts, loropetalum leaf extract 5 parts.

[0079] in:

[0080] The three needles total alkaloid extract is the substance extracted from the three needles by the following method:

[0081] Take three needles of medicinal materials, add 10 times the amount of 0.5% sulfuric acid aqueous solution to soak for 24 hours, then percolate at a speed of 3ml per minute, collect the percolation liquid, add lime milk to the percolation liquid to adjust the pH value to 5, filter, add the filtrate Adjust the pH value to 2 with hydrochloric acid, add sodium chloride to make the salt content reach 8%, let it stand for 24 hours, filter to obtain a precipitate, wash the precipitate with water until the pH value reaches 6, dry, and pulverize to obtain the tot...

Embodiment 3

[0089] The present embodiment is the pharmaceutical composition (hard capsule) that is made by the Chinese medicine extract of following proportioning by weight:

[0090] Three needles total alkaloid extract 2 parts, cucumber root extract 2 parts, loropetalum leaf extract 3 parts.

[0091] in:

[0092] The three needles total alkaloid extract is the substance extracted from the three needles by the following method:

[0093] Take three needles of medicinal materials, add 10 times the amount of 0.6% sulfuric acid aqueous solution and soak for 12 hours, then percolate at a speed of 2ml per minute, collect the percolation liquid, add lime milk to the percolation liquid to adjust the pH value to 5, filter, add the filtrate Adjust the pH value to 1 with hydrochloric acid, add sodium chloride to make the salt content 10%, let it stand for 36 hours, filter to obtain a precipitate, wash the precipitate with water until the pH value reaches 6, dry, and pulverize to obtain the total a...

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Abstract

The invention discloses a traditional Chinese medicine extract compound, which is mainly formed by the traditional Chinese medicine extract. The proportion by weight of the compound is as follows: the total alkaloid extracts of barberry are 1 to 20 parts, the extracts of cucumber roots are 1 to 20 parts, and the extracts of Chinese Loropetalum Herb leaves are 1 to 20 parts. By adopting the conventional traditional Chinese medicine combination formula and combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease, the compound has as fuctions as obvious hypoglycemic effect and microcirculation improvement, etc., effectively treats diabetes mellitus or diabetic complication that is diabetic retinopathy, and has important clinical application significance.

Description

Technical field [0001] The present invention is a pharmaceutical preparation technology field, which involves a composition of Chinese medicine extract and its pharmaceutical use. Background technique [0002] Diabetes Mellitus (DM) is a common metabolic disease in the clinic, characterized by chronic hyperglycemia, accompanied by sugar, fat, and protein metabolic disorders caused by lack of insulin secretion or insulin cell metabolism. [0003] Long -term metabolic abnormalities can cause vascular complications. Diabetic retinopathy (DR) is one of the main chronic complications of diabetes. It is a kind of fundus lesions with specific changes. It is characterized by retinal microvascular changes.It is one of the severe microvascular degeneration of diabetes, which can cause irreversible blindness of the eyes and be the fourth disease that blinds. [0004] Since the 1980s, the number of patients with global diabetes has increased significantly. In 2003, the International Diabete...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/42A61P3/10A61P27/02
Inventor 周小江
Owner 湖南药圣堂中药科技有限公司
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