Nimodipine capsule containing semi-solid combination and preparation

Abstract

The invention discloses a nimodipine capsule with high dissolution and semi-solid composition as content and a preparation method thereof, and belongs to the pharmaceutical preparation field. The method comprises the following steps of mixing micronized nimodipine and a hydrophilic carrier, preparing into solid dispersion by melting extrusion method, cooling, pulverizing, mixing with semi-solid matrix, surfactant, melting point regulator under heating, and filling the content into hard capsule with a capsule filling machine. The invention combines the melting extrusion technique and semi-solid filling hard capsule technique, and after the prepared novel nimodipine capsule is administered into human body, the nimodipine quickly diffuses in molecular form and saturates metabolic enzymes, soas to improve bioavailability. The inventive nimodipine capsule solves the low dissolution and low utilization ratio problems of prior nimodipine preparation; and has the advantages of high dissolution, good stability, simple preparation method, and applicability to industrial production.

Description

A kind of content is the nimodipine capsule of semi-solid composition and preparation method Technical field: The invention belongs to the field of pharmaceutical preparations, and in particular relates to a high-dissolution nimodipine capsule whose content is a semisolid composition and a preparation method thereof. Background technique: Using solid dispersion technology to improve the dissolution rate of poorly water-soluble drugs is a relatively effective method that is more commonly used in recent years. Solid dispersion refers to the dispersion system formed by uniformly dispersing the drug in a certain solid carrier substance in the state of molecule, colloid, amorphous, microcrystalline and so on. The rapid release mechanism is that the dissolution rate of the drug is closely related to its specific surface area, that is, the larger the specific surface area of ​​the drug per unit volume, the higher the dissolution rate, and the carrier itself can promote the dissol...

AI Technical Summary

Problems solved by technology

Purpose of the invention: the present invention provides a kind of content is the high dissolution rate nimodipine capsule of semi-solid composition and preparation method thereof, and its purpose is to solve the low dissolution rate of nimodipine drug in the past and existing nimodipine solid dispersion The body is easy to age, leading to problems such as a decrease in dissolution rate

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