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Hypertension-treating medicine combination

A composition and high blood pressure technology, applied in the direction of drug combination, heterocyclic compound active ingredients, pharmaceutical formulations, etc., can solve the problems of insufficient promotion of disease treatment, great differences in treatment methods, and great differences in pathogenesis, etc., to achieve therapeutic Increased costs, increased compliance with treatment, and the effects of preventing drastic changes in blood pressure

Active Publication Date: 2010-09-08
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
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  • Claims
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Problems solved by technology

Although hypertension, arrhythmia, angina pectoris and myocardial infarction all belong to cardiovascular diseases, their pathogenesis is very different, and the corresponding treatment methods are also very different. However, this invention is only general and does not give any specific The technical scheme of the composition, the embodiment only relates to the preparation method of S-metoprolol, so it is not enough to promote the treatment of the disease and bring a significant boost

Method used

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  • Hypertension-treating medicine combination

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Abstract

The invention provides a novel pharmaceutical composition for treating hypertension, and relates particularly to a pharmaceutical composition comprising S-metoprolol and angiotensin II receptor antagonist, wherein the angiotensin II receptor antagonist includes losartan, valsartan, telmisartan, irbesartan or olmesartan; and the weight ratio of S-metoprolol to angiotensin II receptor antagonist is1:(0.1-5), preferably 1:(0.25-2), more preferably 1:(0.5-1.1). The inventive composition is very important for long-term survival rate of hypertensive patients, and has a positive impact on the prognosis of hypertension for patients.

Description

technical field The invention relates to a pharmaceutical composition for treating hypertension, which belongs to the field of medicine. Background technique Metoprolol (metoprolol) is an aminopropanol drug, a selective β1 receptor blocker, and is the drug of choice for the treatment of hypertension in the world in recent years. It competes with excitatory epinephrine and norepinephrine, and protects the heart at the receptor's site, inhibits cardiac contractility, prevents hyperexcitability, and blocks nerve impulses. It also ensures the contraction of the smooth muscle of the heart wall by itself. The chemical name of metoprolol is: 1-4[(2-methoxyethyl)phenoxy]-3[(1-methoxyethyl)amino]-2propanol, and its structural formula is: Clinically, its hydrochloride, succinate, and tartrate are mainly used. Metoprolol is a chiral molecule with 1 chiral carbon atom and is a racemic mixture of the R+ and S-enantiomers, the S-enantiomer being primarily involved in beta-receptor bl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/12A61K31/4184A61K31/138A61K31/41
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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