External-used burn and scald treating medicine and its preparation

A technology of medicine and extract, which is applied in the field of medicine for treating burns and scalds and its preparation, can solve the problems of ordinary patients, low bioavailability, slow recovery of patients, etc., achieve wide application prospects, promote transdermal absorption, and have no toxicity side effects

Inactive Publication Date: 2008-09-03
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many kinds of medicines for treating burns and scalds, mainly containing 2 classes: the first class is chemically synthesized medicines, such as silver sulfadiazine, etc. These medicines have certain curative effects for treating burns and scalds, but there are many problems and deficiencies: 1. The first is that the elimination of putrefaction skin and bad tissue is slow, and the probability of wound infection increases; the second is that the scabs are slow, which increases water loss and infection; the third is that the patient causes pain when using the drug; the fourth is that the treatment cost is high
The second category

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0020] 1. Preparation of nano-powder of licorice extract: Glycyrrhizae is pulverized by a pulverizer to obtain powder, and the aqueous solution of cellulase with a mass percentage concentration of 0.1-2% is added for treatment for 4-8 hours. The mass ratio of licorice powder to the aqueous solution of cellulase is 1:1~1:3. Then add ethanol or acetone, so that the volume percentage concentration of ethanol is 30-70%, or the volume percentage concentration of acetone is 30-80%, and then extract by flash extractor or microwave-assisted extraction or ultrasonic crushing extraction, and filter the filtrate Concentrate under reduced pressure to a specific gravity of 1.20-1.25, spray dry to obtain micron-scale powder, and prepare nano-scale powder with a particle size of less than 200nm through a planetary ball mill.

[0021] 2. Preparation of comfrey extract nanopowder:

[0022] The comfrey is pulverized by a pulverizer to obtain powder, which is treated with an aqueous solution of...

Embodiment 1

[0030] Weigh 50g of licorice powder, add 50ml of water containing 0.1% cellulase and stir for 8 hours, add ethanol to make the final concentration of ethanol to 70%, extract through flash extractor for 20min, filter with 3 layers of gauze, and concentrate the filtrate to specific gravity under reduced pressure 1.20, the micron-sized powder is obtained by spray drying, and the nano-sized powder with a particle size of less than 200nm is prepared through a planetary ball mill, and the weight of the powder is 12.7g.

Embodiment 2

[0032] Weigh 50 g of licorice powder, add 100 ml of water containing 1% cellulase and stir for 5 hours, add ethanol to make the final concentration of ethanol 30%, extract through an ultrasonic extractor for 15 minutes, filter with 3 layers of gauze, and concentrate the filtrate under reduced pressure to a specific gravity of 1.23 , through spray-drying to obtain micron-scale powder, and through a planetary ball mill to prepare nano-scale powder with a particle size of less than 200nm, and the weight of the powder is 11.8g.

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PUM

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Abstract

The invention relates to a medicine for externally treating burn and scald, which is an ointment prepared from slough tissue of cultured second generation giant salamanders and subsequent generations thereof during growth period, radix glycyrrhizae, borneol, sinkiang arnebia root and sanguisorba officinalis. The inventive ointment is prepared from the radix glycyrrhizae extract, sinkiang arnebia root extract, sanguisorba officinalis extract and nanometer powder of giant salamander slough tissue that are obtained by modern biotechnology. The preparation method og the medicine comprises the steps of mixing according to a certain proportion, adding borneol and matrix that is made of Vaseline, vegetable oil, beeswax and anhydrous lanolin, homogenizing, and making into the ointment. The inventive medicine has the advantages of good therapeutic effect, quick action, good analgesic effect, short treatment course, no scar left, and no any toxic and side effects. Burn and scald rat model experiments prove that the inventive medicine shortens the healing time of the superficial second degree, the deep second degree and the third degree burns, there is no scar left on wound surface after healing for the superficial second degree and the deep second degree burns, and there is less scar left on wound surface after healing the third degree burn, with no need of skin grafting. The inventive medicine has better therapeutic effect than the prior medicines for treating burn and scald, and has very wide application prospect.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a medicine for treating burns and a preparation method thereof. The medicine is prepared from animal and plant tissues as raw materials. Background technique [0002] Burns and scalds with different areas and depths caused by various reasons are common diseases that seriously endanger human health and appearance. Burns refer to the direct burning of flames caused by organic substances, chemical substances, power sources, and radiation on human skin, limbs, and internal organs. The degree of harm to the human body is relatively large, and treatment and treatment methods are relatively difficult; scalds refer to liquids that are higher than the body temperature Burns to the surface and deep layers of human skin by solid, gaseous substances, such as water, oil, chemical agents, acids, alkalis, iron, aluminum, copper, bricks, stones, asphalt, steam, etc. scald. Burns and scalds mainly occur ...

Claims

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Application Information

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IPC IPC(8): A61K36/739A61K47/44A61P17/02A61K31/045A61K35/60
Inventor 余龙江郭文韬敖明章王健文
Owner HUAZHONG UNIV OF SCI & TECH
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