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Bee venom injection preparation

A technology for injection preparation and injection, which can be used in pharmaceutical formulations, drug delivery, non-central analgesics, etc., can solve problems such as severe irritation and allergic reactions, and achieve the effects of excellent preparation and simple process.

Inactive Publication Date: 2008-09-10
石海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In practice, we realize that bee venom injection is more irritating and occasionally allergic reactions occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example

[0013] a. Take 20g of bee venom, dissolve it with 200ml of water for injection, put it into a 500ml separating funnel, add 100ml of ether to extract twice. Release the water layer, heat to boiling, keep for 30 minutes, evaporate the remaining ether, and add water to 200ml.

[0014] b. Take about 200g of Sephadex G-50, soak it with 100 times water for injection for 12 hours, wash it repeatedly with water for injection 3 times (remove fine particles), put it into the chromatography column, connect the water supply system, and use Rinse with water for injection for 2 hours and set aside.

[0015] c. Add the bee venom aqueous solution to the dextran gel column for separation and extraction. The liquid outlet is monitored by an ultraviolet monitoring recorder, the flow rate is controlled at 5ml per minute, and the monitoring wavelength is 280nm. When any component flows out, it will start to receive and collect about 28 Hours, until the monitor has no absorption peak.

[0016] d....

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PUM

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Abstract

Bee venom injection liquid is the sterilization aqueous solution of bee venom and is used for remedying the rheumatoid or rheumatoid arthritis, the peripheral neuritis and the neuralgia. The present invention introduces a preparation method of the sterilization aqueous solution. The process of the preparation method is that aether is used for extraction after water is dissolved; the aether is volatilized out; sephadex gel G-50 is used for separating; a 0.1 million molecular weight hyperfiltration pole is used for hyperfiltration; the bee venom injection liquid can be obtained after aseptic filtration, encapsulation and sterilization. The bee venom injection liquid has the advantage of removing the inflammatory substance such as 5-hydroxytryptamine etc. and macromolecular protein in the bee venom, so as to weaken the excitability and the irritability of the bee venom injection liquid and improve the curative effect and stability of the bee venom injection liquid.

Description

Technical field: [0001] The present invention belongs to the technical field of medicine. Background technique: [0002] Bee venom injection is a sterilized aqueous solution of bee venom, which has anti-inflammatory and analgesic effects, and is used to treat rheumatoid arthritis, rheumatoid arthritis, peripheral neuritis and neuralgia. In practice, we realize that bee venom injection is more irritating and occasionally allergic reactions occur. Because it contains relatively small substances such as high molecular weight protein and its inflammatory substances such as hyaluronic acid enzyme and 5-hydroxytryptamine. This patent utilizes the molecular sieve separation principle of dextran gel to separate smaller inflammatory substances from active ingredients of bee venom to reduce irritation. The ultrafiltration column with a molecular weight of 100,000 is used to separate the high-molecular substances from the active ingredients of bee venom, which weakens the allergy of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/08A61P29/00
Inventor 石海
Owner 石海
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