Applications of iron chelator in preparation of medicament for preventing or curing hemorrhagic cerebrovascular disease and chronic hydrocephalus after craniocerebral injury

Abstract

The invention discloses an application of an iron ion chelant in a preparation of a drug for preventing or treating hemorrhagic cerebrovascular disease and chronic hydrocephalus after craniocerebral injury; an animal experimental research shows that the iron ion has something to do with the emergence of the chronic hydrocephalus after ventricular hemorrhage; the iron ion chelant is capable of eliminating excessively accumulated iron ion in cerebrospinal fluid (CSF), lightening brain tissue damage caused by the iron ion, effectively reducing the incidence rate of ventricular hemorrhage hydrocephalus of a big mouse, improving the learning memory abilities of the big mouse with the ventricular hemorrhage, thereby being used for preparing the drug for preventing or treating the hemorrhagic cerebrovascular disease and the chronic hydrocephalus after the craniocerebral injury.

Description

technical field [0001] The invention relates to the field of therapeutic activity of pharmaceutical preparations, in particular to the application of iron ion chelating agents in the preparation of medicines for preventing or treating hemorrhagic cerebrovascular disease and chronic hydrocephalus after craniocerebral injury. Background technique [0002] Hydrocephalus is a common complication of hemorrhagic cerebrovascular disease and craniocerebral injury. At present, although cerebrospinal fluid shunt surgery and third ventriculostomy can be used for treatment, the overall effect is not good; and because the mechanism of hemorrhagic cerebrovascular disease and chronic hydrocephalus after craniocerebral injury is still unclear, it is difficult to treat it in the brain. Do a good job of prevention and treatment early after bleeding. Recent studies have shown that blood catabolite iron ions play an important role in the secondary brain damage after cerebral hemorrhage, but wh...

AI Technical Summary

Problems solved by technology

Studies have found that iron ion chelating agents such as deferoxamine can enter the brain parenchyma through the blood-brain barrier and accumulate to a higher concentration. Through chelation, the excessive accumulation of iron ions in the brain can be removed, and the concentration of iron ions in the cerebrospinal fluid can be effectively reduced. Desferoxamine after cerebral hemorrhage can effectively reduce cerebral edema and neurological dysfunction, but so far, there is no report on the use of iron ion chelators for the prevention or treatment of hemorrhagic cerebrovascular disease and chronic hydrocephalus after craniocerebral injury

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