Use of composition of isoflavonoids from Belamcanda chinensis in preparing anti-hepatitis medicament

A compound and isoflavone technology, applied in the field of natural medicine, to achieve significant anti-hepatitis B virus effect

Inactive Publication Date: 2008-11-12
上海双科医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there are no reports on the anti-hepatitis B virus of compounds such as irisaxanthin, irisinin, irisin and irisin

Method used

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  • Use of composition of isoflavonoids from Belamcanda chinensis in preparing anti-hepatitis medicament
  • Use of composition of isoflavonoids from Belamcanda chinensis in preparing anti-hepatitis medicament
  • Use of composition of isoflavonoids from Belamcanda chinensis in preparing anti-hepatitis medicament

Examples

Experimental program
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Effect test

Embodiment Construction

[0011] The present invention will be further described below through specific implementation examples.

[0012] Anti-hepatitis B virus test of iridinin (BC-1), iridinin (BC-3), iridinin (BC-13) and iridinin (BC-14)

[0013] 1. Experimental drugs, reagents and materials

[0014] Compounds BC-1, BC-3, BC-13, BC-14.

[0015] Readable HBsAg Diagnostic Kit (Shanghai Kehua Biotechnology Co., Ltd.)

[0016] Readable HBeAg Diagnostic Kit (Shanghai Kehua Biotechnology Co., Ltd.)

[0017] Cell culture medium (10% fetal bovine serum, 0.03% glutamine, G418 390μg / ml, kanamycin 50U / ml, adjust pH to 7.2)

[0018] Cell digestion solution (0.25% trypsin, prepared with phosphate buffer)

[0019] The HBV-DNA clone was transfected into the 2.2.15 cell line of human liver cancer cells (HepG2215).

[0020] 2. Method

[0021] Cells in the logarithmic growth phase (HepG2.2.15), adjust the cell concentration to 2×105 cells / ml, take 100 μl of 96-well plate; add the drug after diluting and culturi...

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Abstract

The invention belongs to the medical technical field, in particular relating to an application of isoflavonoids from Belamcanda chinensis in the preparation of anti-hepatitis virus drugs. A Hepatitis B surface antigen (HBsAg) detection reagent test and a hepatitis B core antigen (HBeAg) detection reagent test are performed, and the results indicate that the isoflavonoids from the Belamcanda chinensis can remarkably suppress hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBeAg) and has remarkable effect on preventing and treating hepatitis B viruses. Therefore, the isoflavonoids from the Belamcanda chinensis can be used to prepare medicines or health-care food used to prevent and treat the hepatitis viruses.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to the application of isoflavone compounds in Shegan Belamcanda chinensis (L.) DC. in the preparation of anti-hepatitis virus drugs or health food. Background technique [0002] Shegan is the dry rhizome of Belamcanda chinensis (L.) DC. It has been reported that the main components contained in Shegan are 19 isoflavone bud components such as irisgenin, irisxanthin, subirisaxanthin, irisoflavone neoaglycone A, white sheganin, irisin, and irisin [Jin Li, Chen Hai-Sheng et al. New flavone andisoflavone glycoside from Belamcanda chinensis, Chinese Chemical Letters 2007, 18: 158-160; Jin Li, Chen Hai-sheng * , Jin Yong-Sheng, Liang Shuang, Liu Jian-GuoChemical constituents from Belamcanda chinensis Journal of Asian Natural Products Research2008, 10(1): 89-91; Hu Xiaolan, Xu Shi, Huang Tianxia, ​​etc., Separation and identification of chemical constituents in Shegan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61P1/16A61P31/12A23L1/30A23L33/105
Inventor 陈海生
Owner 上海双科医药科技有限公司
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