Crataegutt oral freeze-dried tablet and preparation thereof

A technology for freeze-dried tablets and Yixin ketone is applied in the field of traditional Chinese medicine preparations and can solve the problems of low bioavailability, slow dissolution of dosage forms, and difficulty in swallowing.

Inactive Publication Date: 2008-11-12
海南高升医药科技开发股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to solve the problems of slow dissolution,

Method used

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  • Crataegutt oral freeze-dried tablet and preparation thereof
  • Crataegutt oral freeze-dried tablet and preparation thereof
  • Crataegutt oral freeze-dried tablet and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 The preparation of oral freeze-dried tablet of the present invention

[0028]

[0029]

[0030] Preparation:

[0031] Step 1: Take the above-mentioned excipients and place them in a 2000ml container, add an appropriate amount of water, stir and dissolve at a temperature of 50°C to 70°C, and form a colorless and clear solution.

[0032] Step 2: Weigh the total flavonoids of hawthorn leaf as the main drug in the prescribed amount, place it in the above solution, and stir to dissolve it into a dark red solution.

[0033] Step 3: Add water to the full amount and stir to mix evenly.

[0034] Step 4: Take the above-mentioned mixed solution and pack it into molds by 4.5ml, and then make the finished product by the following freeze-drying process.

[0035] Freeze-drying process: Pre-freeze at -60°C for 3 to 5 hours. Under vacuum and low temperature conditions, the sample is dried at a rate of 4°C / h to 0°C for the first drying, and then at a rate of 6°C / h to...

Embodiment 2

[0041] Embodiment 2 Preparation of oral freeze-dried tablet of the present invention

[0042]

[0043] Preparation:

[0044] Step 1: Take the above-mentioned excipients and place them in a 2000ml container, add an appropriate amount of water, stir and dissolve at a temperature of 50°C to 70°C, and form a colorless and clear solution.

[0045] Step 2: Weigh the total flavonoids of hawthorn leaf as the main drug in the prescribed amount, place it in the above solution, and stir to dissolve it into a dark red solution.

[0046] Step 3: Add water to the full amount and stir to mix evenly.

[0047] Step 4: Take the above-mentioned mixed solution and pack it into molds by 4.5ml, and then make the finished product by the following freeze-drying process.

[0048]Freeze-drying process: pre-freezing at 60°C for 3-5 hours, under vacuum and low temperature conditions, the sample is dried at a rate of 4°C / h to 2°C for the first drying, and then at a rate of 6°C / h to 30 ℃ for secondar...

Embodiment 3

[0054] Embodiment 3 The preparation of oral freeze-dried tablet of the present invention

[0055]

[0056] Preparation:

[0057] Step 1: Take the above-mentioned excipients and place them in a 2000ml container, add an appropriate amount of water, stir and dissolve at a temperature of 50°C to 70°C, and form a colorless and clear solution.

[0058] Step 2: Weigh the total flavonoids of hawthorn leaf as the main drug in the prescribed amount, place it in the above solution, and stir to dissolve it into a dark red solution.

[0059] Step 3: Add water to the full amount and stir to mix evenly.

[0060] Step 4: Take the above-mentioned mixed solution and pack it into molds by 4.5ml, and then make the finished product by the following freeze-drying process.

[0061] Freeze-drying process: pre-freeze at -60°C for 3 to 5 hours, and then rise to -2°C at a rate of 4°C / h for the first drying of the sample under vacuum and low temperature conditions, and then rise to Perform secondar...

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Abstract

The invention belongs to the Chinese medicine preparation technical field, in particular relating to a Yixintong oral freeze-dry disintegrating tablet and a method for preparing the same. The method adopts hawthorn leaf total flavonoids as active ingredients, prepares solution through addition of adequate filler, adhesives, correctives and water and then prepares a novel dosage form of the oral freeze-dry disintegrating tablet after freeze drying. The result of animal experiments verifies that the bioavailability is high and then the potency can be given play quickly.

Description

technical field [0001] The invention specifically relates to a traditional Chinese medicine oral freeze-dried tablet containing total flavonoids of hawthorn leaves, which can be quickly dissolved in the mouth, has good taste, good mechanical strength, is not easy to break, is not easy to drop powder, and is convenient to take and a preparation method thereof. It belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the diseases with a higher prevalence in the world. Among them, high blood pressure, high blood fat, oxidized low-density lipoprotein, oxygen free radicals, etc. are the main factors leading to cardiovascular and cerebrovascular diseases, and these diseases are often caused by the elderly. Yixindone Tablets, with the total flavonoids of hawthorn leaves as the main active ingredient, are the most effective and safest medicine for preventing and treating card...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61K9/20A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61P9/00A61K127/00A61K47/10
Inventor 王小树杨贵方刘红
Owner 海南高升医药科技开发股份有限公司
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