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Instrumentality for sequestering liquids based on density: method and apparatus

A device, liquid technology, applied in the field of blood component separation

Active Publication Date: 2008-11-26
THERMOGENESIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The bags are then placed in a centrifuge for component separation

Method used

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  • Instrumentality for sequestering liquids based on density: method and apparatus
  • Instrumentality for sequestering liquids based on density: method and apparatus
  • Instrumentality for sequestering liquids based on density: method and apparatus

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Embodiment Construction

[0101] Considering the drawings, in which like reference numerals identify like parts throughout, reference numeral 10 as shown in FIG. 3 refers to a set of bags according to the invention.

[0102] In general, the bag set 10 includes a whole blood processing bag 2, a red blood cell (RBC) bag 4 with a hanger 16, and a freezing bag 6 for collecting and storing white blood cells. The treatment bag 2 is supplied via the inlet line 12, via the phlebotomy needle 8 (Fig. 10) or by piercing, sterile docking into another bag containing anticoagulated blood. The disposal bag 2 has an asymmetrical shape comprising a top side 11a , a short side 11b , a long side 11c and a sloping bottom side 11d between the sides such that the bottom tapers into the asymmetrical point 14 leading to the outlet 26 .

[0103] The asymmetric processing bag allows the concentration of the monocyte fraction of the leukocyte population to exclude 30-50% of the granulocytes within a certain time frame. Granuloc...

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Abstract

The invention provides a device and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. The sensor is capable of reading one or several characteristics as follows: infrared ray, optics, density, weight, radiation phenomenon, fluorescence, colour, magnetic force, ultrasonic wave and capacitance. The characteristic is inherent characteristic of blood and blood components or additive. Each component may then be separated into its own storage container. Preferable sensor comprises optical and weight sensors. Beside density separation of blood, the device may comprise solution of cells, proteins, sub-cellular particles or viruses which are capable of mixing with affinity medium or antibody before separation.

Description

technical field [0001] The following inventions generally relate to means and methodology for the separation of blood components. More specifically, the present invention is directed to methods and apparatus for collecting blood samples and subsequently separating the collected samples into constituent blood components for independent storage or use. Background technique [0002] Blood collection is always important, especially in times of emergency (immediate use), but whole blood can only be stored for about 30 days before it "expires". For long-term storage, the ability to separate whole blood into its main components (leukocytes, platelets, erythrocytes, and plasma) is of paramount importance, since the long-term storage conditions of the individual components differ in temperature and storage medium. The most important fractionation that occurs after collection is that of red blood cells (RBC), white blood cells (WBC), platelets, and plasma from each other. Within WBC...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B19/00B04B3/00B01D21/26B01D29/11B04B1/00
CPCA61M1/3693A61M1/0209A61M1/0272A61M1/0281B04B5/0428B04B2005/0435A61M1/0231A01N1/00A01N1/02
Inventor P·H·克尔霍E·索默R·克洛辛克斯基J·霍布斯B·贝克B·马洛恩
Owner THERMOGENESIS
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