Environment-friendly type niclosamide sustained-release block and preparation method thereof

A technology for niclosamide and niclosamide ethanolamine salt, which is applied in the field of environment-friendly niclosamide sustained-release blocks and their production, can solve problems such as difficulty in large-scale application of snail control and excide on-site, and achieves low price , the effect of reducing costs

Inactive Publication Date: 2008-12-10
熊海波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the production process, production scale, slow-release effect, environmental protection and other reasons, there are certain difficulties in the large-scale application of molluscicide and larvae killing on-site

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: (floating type)

[0023] 1. Material preparation: dry the sawdust and sieve it with 10-30 mesh, and sieve the perlite with 10-30 mesh;

[0024] 2. Adhesive preparation: wash the iron pot, add tap water, boil the water at 100°C, add 3kg of polyvinyl alcohol particles, turn off the heat, and stir thoroughly. After the polyvinyl alcohol particles are completely dissolved, Turn off the fire source and set aside after cooling;

[0025] 3. Production: Weigh 30kg of sawdust and 20kg of perlite according to the proportion, add the raw materials into the mixer and stir them thoroughly, then add 50kg of wettable powder of niclosamide ethanolamine salt, stir fully, add the adhesive polyvinyl alcohol, and then fully stir After entering the machine press into a round cake Serve product.

Embodiment 2

[0026] Embodiment two: (sinking type)

[0027] 1. Material preparation: dry the sawdust and sieve it with 10-30 mesh, dry and pulverize the red soil and sieve it with 10-30 mesh;

[0028] 2. Adhesive preparation: wash the iron pot, add tap water, boil the water at 100°C, add 3kg of polyvinyl alcohol particles, turn off the heat, and stir thoroughly. After the polyvinyl alcohol particles are completely dissolved, Turn off the fire source and set aside after cooling;

[0029] 3. Production: Weigh 20kg of sawdust and 30kg of red soil according to the proportion, add the raw materials into the mixer and stir them thoroughly, then add 50kg of niclosamide ethanolamine salt wettable powder, add the adhesive polyvinyl alcohol after fully stirring, and then fully stir Enter the machine and press it into a round cake-shaped product.

[0030] The slow-release block after compression molding is in the shape of a 8×3cm round cake, with a 0.5cm round hole in the middle, which is convenien...

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PUM

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Abstract

The invention relates to a medicament used for killing oncomelania and schistosoma japonicum cercaria, in particular to an environmental-protection typed niclosamide slow releasing block and a preparation method thereof. The best proportioning of the slow releasing block of the invention according to the weight portions is 50 portions of niclosamide ethanolamine salt wettable powder, 30 portions of sawdust, 20 portions of perlite and 3 portions of polyvinyl alcohol for the upper floating type and is 50 portions of niclosamide ethanolamine salt wettable powder, 20 portions of sawdust, 30 portions of red soil and 3 portions of polyvinyl alcohol. The invention uses the niclosamide recommended by WHO as the main medicament; the adopted carrier material is sawdust which has low price and causes no environmental pollution; more than 6,000m<2> can be released in the operation of two persons each day, thus saving the niclosamide by 50% and the cost by 40%.

Description

technical field [0001] The invention relates to a medicine for killing oncomelania and schistosome cercariae, in particular to an environment-friendly niclosamide slow-release block and a preparation method thereof. Background technique [0002] In schistosomiasis-endemic areas, snails are the intermediate hosts of schistosomiasis, and the prevalence of schistosomiasis can be controlled by eliminating snails or their escaped cercariae. Niclosamide is currently the only effective and low-toxic drug recommended by the World Health Organization for killing snails and cercariae. Only Waizhou, Hunan Province has an area of ​​2.6 million mu of oncomelania. Hundreds of tons of niclosamide are invested in mollusc control every year, consuming more than tens of millions of manpower, material and financial resources, but the area of ​​mollusc control is less than 1 / 6. Can not effectively control the prevalence of schistosomiasis. And the amount of molluscicide is large, which affec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/08A01N37/22A01P9/00A01P7/00
Inventor 熊海波
Owner 熊海波
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