Medicament composition for eyes and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, active ingredients of heterocyclic compounds, etc., to achieve the effects of reducing the degree of disease, shortening the course of disease, and avoiding troubles

Inactive Publication Date: 2009-01-14
GRAND PHARM (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] Through searching patents and documents, there is no patent and document public report on combining ganciclo

Method used

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  • Medicament composition for eyes and preparation method thereof
  • Medicament composition for eyes and preparation method thereof
  • Medicament composition for eyes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: Preparation of Ganciclovir / Dexamethasone Composition Eye Drops:

[0040] 1) Prescription:

[0041] Ganciclovir 8g

[0042] Dexamethasone 0.08g

[0043] Boric acid 1g

[0044] Sodium borate 1.5g

[0045] Sodium Hyaluronate 8g

[0046] Tween-80 12g

[0047] Brogeramine 0.8g

[0048] Sodium chloride 20g

[0049] Water for injection to 8000ml

[0050]

[0051] A total of 1000 eye drops were made

[0052] 2) Preparation method:

[0053] According to the aseptic method, put ganciclovir, dexamethasone and Tween-80 in a reaction tank, add water for injection, heat to dissolve, add other additives in the above prescription, and adjust the pH to 6.0 with hydrochloric acid -7.0, boil for 5-10min, cool to room temperature, filter with a 0.22μm microporous membrane under clean conditions, add water for injection to the full amount, stir well, take a sample to determine the pH and content, and aseptically fill it into 8mL eye dro...

Embodiment 2

[0061] Embodiment 2: Preparation of penciclovir / dexamethasone composition eye drops:

[0062] 1) Prescription:

[0063] Penciclovir 8g

[0064] Dexamethasone 0.16g

[0065] Boric acid 1g

[0066] Sodium borate 1.5g

[0067] Tween-80 12g

[0068] Brogeramine 0.8g

[0069] Sodium chloride 24g

[0070] Water for injection to 8000ml

[0071]

[0072] A total of 1000 eye drops were made

[0073] 2) preparation method: with embodiment 1.

Embodiment 3

[0074] Embodiment 3: Preparation of Ganciclovir / Dexamethasone Composition Eye Drops:

[0075]Preparation method: add 0.16ml (0.16mg) of dexamethasone injection (specification 1ml: 1mg) to commercially available 8ml (8mg) of ganciclovir eye drops, take a sample to determine the pH and content, after passing the test, in a clean condition Sealed at the bottom, stored at room temperature and set aside.

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Abstract

The invention relates to a medicine composition and a preparation method thereof, in particular to an ophthalmic medicine composition and a preparation method thereof. The ophthalmic medicine composition comprises an antivirus medicine with 0.005 to 5.0 weight percent of effective dose, DXM with 0.0005 to 0.1 weight percent of the effective dose and medicinal additive. The medicine composition used for curing herpes simplex keratitis can greatly enhance the recovery process of the herpes simples keratitis and deep solid herpes simples keratitis, effectively improve eye irritation symptoms, shorten healing time and reduce the recurrence rate of the herpes simples keratitis.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to an ophthalmic pharmaceutical composition and a preparation method thereof, and the composition is used for treating herpes simplex virus keratitis. Background technique [0002] Herpes simplex virus keratitis, referred to as herpes simplex virus keratitis, is keratitis caused by herpes simplex virus. It is mainly a corneal lesion caused by herpes simplex virus type I infection. According to statistics, the keratitis caused by HSV-I infection has nearly 1 million blindness every year in the world, and the incidence rate in my country is also quite high. Every year, 50,000 people are blind or have a significant decrease in vision due to corneal virus infection. HSK has the characteristics of repeated illness and difficult to cure. [0003] Currently used antiviral drugs for the treatment of herpes virus keratitis such as acyclovir (Acyclovir, Acyclov...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K31/52A61K31/522A61P27/02
Inventor 黄璐杨波周建明郭亚兵赵蓉
Owner GRAND PHARM (CHINA) CO LTD
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