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Banksia rose capsule, preparation method and quality control method thereof

A woody, capsule-based technology, applied in capsule delivery, measuring devices, pharmaceutical formulations, etc., can solve the problems of being the first choice and not being able to be used as a gastric motility drug, and achieve the effects of promoting release, removing adverse reactions and side effects, and good therapeutic effect

Active Publication Date: 2009-01-14
SHIJIAZHUANG HUAXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are four commonly used drugs in clinical practice: metoclopramide, domperidone, cisapride and erythromycin, but because of their clinical side effects, none of them can be used as the first choice for gastric motility drugs

Method used

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  • Banksia rose capsule, preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Get 500g of cassava crude powder and place it in the extractor, and use CO 2 Get rid of the air in the extractor, adjust the pressure and temperature of the extractor and separator, the extraction temperature is 25°C, the extraction pressure is 10Mpa, CO 2Under the condition of flow rate of 21-25L / h, continuous extraction for 2 hours, analysis under the condition of pressure of 5Mpa and temperature of 35°C, extract brown-red or brown-yellow translucent oil, take the extract from the separator, and centrifuge Moisture is removed to obtain the total lactones of woody wood. The extraction rate is 3.32%, the total lactone content is 60.2%, and the content of dehydrocressin is 31.9%.

Embodiment 2

[0049] Get 500g of cassava crude powder and place it in the extractor, and use CO 2 Get rid of the air in the extractor, adjust the pressure and temperature of the extractor and separator, the extraction temperature is 35°C, the extraction pressure is 10Mpa, CO 2 Continuous extraction for 4 hours at a flow rate of 21-25L / h, analysis at a pressure of 6Mpa and a temperature of 40°C, extract brown-red or brown-yellow translucent oil, take the extract from the separator, and centrifuge Moisture is removed to obtain the total lactones of woody wood. The extraction rate is 2.86%, and the total lactone content is 58.1%. , the content of dehydrocosmolide is 30.8%.

Embodiment 3

[0051] Get 500g of cassava crude powder and place it in the extractor, and use CO 2 Get rid of the air in the extractor, adjust the pressure and temperature of the extractor and separator, and the extraction temperature is 40°C, the extraction pressure is 25Mpa, CO 2 Under the condition of a flow rate of 21-25L / h, continuous extraction for 3 hours, analysis at a pressure of 6Mpa and a temperature of 40°C, a brown-red or brown-yellow translucent oil is extracted, and the extract is taken out from the separator and centrifuged Moisture is removed to obtain the total lactones of woody wood. The extraction rate is 2.60%, the total lactone content is 54.2%, and the dehydrocressine content is 28.7%.

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Abstract

The present invention provides a costus dynamic capsule and a preparation method thereof, as well as a quality control method. In each costus dynamic capsule of the present invention, the content of dehydro- costuslactone is higher than 9mg and the content of total costuslactone is higher than 22.5mg. The present invention adopts CO Y-[2] supercritical extraction technology; the extraction pressure is 10 to 25MPa, the temperature is 25 to 40 DEG C, the time is 2 to 4 hours and the analysis is carried out under 5 to 6MPa pressure and 35 to 40 DEG C temperature. The preparation method provided by the present invention has the advantages of high extraction rate, no residual organic solvent, simple flow and convenient operation.

Description

technical field [0001] The invention relates to a muxiang power capsule, a preparation method and a quality control method thereof. It belongs to the field of medical technology. Background technique [0002] Gastric motility disorder is a common and frequently-occurring disease in clinical practice. In my country, with social development, environmental changes, population structure and changes in people's lifestyles, the incidence of stomach problems mainly caused by smoking, drinking, emotional stress, drug stimulation, etc. has gradually increased. On the other hand, stomach discomfort and gastric motility problems caused by social pressure and work-related reasons such as irregular eating and irregular eating are also on the rise. [0003] For a long time, chemical drugs have played the leading role in the treatment of gastric motility disorders, and the side effects of chemical drugs are a difficult problem in the medical field. At present, there are four commonly us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/285A61K9/48A61P1/14G01N30/90G01N30/36A61K125/00
Inventor 冯丽王润彪段春改张硕崔振杰马海波
Owner SHIJIAZHUANG HUAXIN PHARMA
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