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Peppermint prescription particle, preparation method and quality control method thereof

Active Publication Date: 2009-01-14
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • Peppermint prescription particle, preparation method and quality control method thereof
  • Peppermint prescription particle, preparation method and quality control method thereof
  • Peppermint prescription particle, preparation method and quality control method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: Peppermint formula granules of the present invention

[0048] The quality of the raw mint is identified by infrared fingerprints. The identification method of infrared fingerprints is: use a Fourier transform infrared spectrometer with a measuring range of 4000cm -1 -400cm -1 , DTGS detector, resolution 4cm -1 , the number of scans is 16 times, the interference of water and carbon dioxide is always deducted during the scanning process, the relative humidity of the environment is lower than 60%, and the potassium bromide direct tablet method is used for detection; the similarity between the obtained results and the mint standard infrared fingerprint is 96%; the mint standard The specific characteristics of the infrared fingerprint spectrum are: the strongest peak: the peak position is 1648cm -1 ;Second strong peak: peak position 1070cm -1 ;Stronger peak: peak position 2926cm -1 ; At the same time, according to the peak intensity from high to low must ha...

Embodiment 2

[0050] Embodiment 2: Peppermint formula granules of the present invention

[0051] The quality of the raw mint is identified by infrared fingerprints. The identification method of infrared fingerprints is: use a Fourier transform infrared spectrometer with a measuring range of 4000cm -1 -400cm -1 , DTGS detector, resolution 4cm -1 , the number of scans is 16 times, the interference of water and carbon dioxide is always deducted during the scanning process, and the relative humidity of the environment is lower than 60%. The specific characteristics of the infrared fingerprint spectrum are: the strongest peak: the peak position is 1648cm -1 ;Second strong peak: peak position 1070cm -1 ;Stronger peak: peak position 2926cm -1 ; At the same time, according to the peak intensity from high to low must have 1416cm -1 、1260cm -1 、1320cm -1 、621cm -1 、771cm -1 5 peaks;

[0052] Get 1000kg of peppermint, extract the volatile oil of peppermint with direct steam method, and obtai...

Embodiment 3

[0053] Embodiment 3: Peppermint formula granules of the present invention

[0054] The quality of the raw mint is identified by infrared fingerprints. The identification method of infrared fingerprints is: use a Fourier transform infrared spectrometer with a measuring range of 4000cm -1 -400cm -1 , DTGS detector, resolution 4cm -1 , the number of scans is 16 times, the interference of water and carbon dioxide is deducted from time to time during the scanning process, the relative humidity of the environment is lower than 60%, and the potassium bromide direct compression method is used for detection; the obtained results are consistent with the standard infrared fingerprint of mint; the specific characteristics of the standard infrared fingerprint For: the strongest peak: peak position 1648cm -1 ;Second strong peak: peak position 1070cm -1 ;Stronger peak: peak position 2926cm -1; At the same time, according to the peak intensity from high to low must have 1416cm -1 、1260cm...

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Abstract

The invention discloses a herbal menthae ingredient particle and a preparation method and a quality control method thereof. The ingredient particle uses the herbal menthae as raw materials. The herbal methae is processed by quantitative extraction and quantitative volatile oil is added. The herbal methae and the volatile oils are processed by water extraction, inclusion and spray drying, and the like, to obtain spray drying herbal menthae powder. The herbal menthae ingredient particle is prepared by the spray drying herbal menthae powder directly or by the spraying drying herbal menthae powder and the auxiliary materials with proper amount. Every gram of the herva menthae ingredient particle of the invention is provided with an IR fingerprint spectra indicated as a Fig3. The preparation method of the invention adopts the quantitative equivalent extracting addition method of the volatile oil so as to ensure drug effect and reduce toxicity and side effects. The technology of the IR fingerprint spectra is adopted by the invention for quality control and the quality control method is scientific, advanced, quick and highly feasible.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule, a preparation method and a quality control method thereof, in particular to a peppermint formula granule, a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. Peppermint formula granules are one of the commonly used traditional Chinese medicine formula granules. At present, mint...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K9/16G01N21/35G01N21/3563
Inventor 付静
Owner BEIJING KANGRENTANG PHARMA
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